Information de reference pour ce titreAccession Number: | 00005768-200011000-00009.
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Author: | DERCHAK, P. ALEXANDER; STAGER, JOEL M.; TANNER, DAVID A.; CHAPMAN, ROBERT F.
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Institution: | Human Performance Labs, Department of Kinesiology, Indiana University, Bloomington IN 47405
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Title: | |
Source: | Medicine & Science in Sports & Exercise. 32(11):1873-1879, November 2000.
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Abstract: | DERCHAK, P. A., J. M. STAGER, D. A. TANNER, and R. F. CHAPMAN. Expiratory flow limitation confounds ventilatory response during exercise in athletes. Med. Sci. Sports Exerc., Vol. 32, No. 11, pp. 1873-1879, 2000.
Introduction: A significant number of highly trained endurance runners have been observed to display an inadequate hyperventilatory response to intense exercise. Two potential mechanisms include low ventilatory responsiveness to hypoxia and ventilatory limitation as a result of maximum expiratory flow rates being achieved.
Purpose: To test the hypothesis that expiratory flow limitation can complicate determination of ventilatory responsiveness during exercise the following study was performed.
Methods/Materials: Sixteen elite male runners were categorized based on expiratory flow limitation observed in flow volume loops collected during the final minute of progressive exercise to exhaustion. Eight flow limited (FL) ( O2max, 75.9 +/- 2.4 mL[middle dot]kg-1[middle dot]min-1; expiratory flow limitation, 47.3 +/- 20.4%) and eight non-flow limited subjects (NFL) ( O2max, 75.6 +/- 4.8 mL[middle dot]kg-1[middle dot]min-1; expiratory flow limitation, 0.3 +/- 0.8%) were tested for hypoxic ventilatory responsiveness (HVR).
Results: Independent groups ANOVA revealed no significant differences between FL and NFL for O2max, E max (136.2 +/- 16.0 vs 137.5 +/- 21.6 L[middle dot]min-1), E/ O2 (28.4 +/- 3.2 vs 27.6 +/- 2.9 L[middle dot]lO2-1), E/ CO2 (24.8 +/- 3.1 vs 24.4 +/- 2.0 L[middle dot]lCO2-1), HVR (0.2 +/- 0.2 vs 0.3 +/- 0.1 L[middle dot]%SaO2-1), or SaO2 at max (89.1 +/- 2.4 vs 86.6 +/- 4.1%). A significant relationship was observed between HVR and SaO2 (r = 0.92, P <= 0.001) in NFL that was not present in FL. Conversely, a significant relationship between E/ O2 and SaO2 (r = 0.79, P <= 0.019) was observed in FL but not NFL. Regression analysis indicated that the HVR-SaO2 and SaO2- E/ O2 relationships differed between groups.
Discussion: When flow limitation is controlled for, HVR plays a more significant role in determining SaO2 in highly trained athletes than has been previously suggested.
(C) 2000 Lippincott Williams & Wilkins, Inc.
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Author Keywords: | EXERCISE VENTILATION; HYPOXIC VENTILATORY RESPONSE; FLOW-VOLUME LOOPS; EXERCISE-INDUCED HYPOXEMIA; ELITE ATHLETES.
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Language: | English.
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Document Type: | BASIC SCIENCES: Original Investigations.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0195-9131
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NLM Journal Code: | 8005433, mg8
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