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Factors Associated With Mortality in Low-Risk Pediatric Critical Care Patients in The Netherlands*.
Verlaat, Carin W. MD; Visser, Idse H. MSc, MA; Wubben, Nina; Hazelzet, Jan A. MD, PhD; Lemson, Joris MD, PhD; van Waardenburg, Dick MD, PhD; van der Heide, Douwe RN; van Dam, Nicolette A. MD; Jansen, Nicolaas J. MD, PhD; van Heerde, Mark MD, PhD; van der Starre, Cynthia MD, PhD; van Asperen, Roelie MD, PhD; Kneyber, Martin MD, PhD, FCCM; van Woensel, Job B. MD, PhD; van den Boogaard, Mark RN, PhD; van der Hoeven, Johannes MD, PhD; on behalf of the SKIC (Dutch Collaborative PICU Research Network)
[Article] Pediatric Critical Care Medicine. 18(4):e155-e161, April 2017.

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Objective: To determine differences between survivors and nonsurvivors and factors associated with mortality in pediatric intensive care patients with low risk of mortality.

Design: Retrospective cohort study.

Setting: Patients were selected from a national database including all admissions to the PICUs in The Netherlands between 2006 and 2012.

Patients: Patients less than 18 years old admitted to the PICU with a predicted mortality risk lower than 1% according to either the recalibrated Pediatric Risk of Mortality or the Pediatric Index of Mortality 2 were included.

Interventions: None.

Measurements and Main Results: In total, 16,874 low-risk admissions were included of which 86 patients (0.5%) died. Nonsurvivors had more unplanned admissions (74.4% vs 38.5%; p < 0.001), had more complex chronic conditions (76.7% vs 58.8%; p = 0.001), were more often mechanically ventilated (88.1% vs 34.9%; p < 0.001), and had a longer length of stay (median, 11 [interquartile range, 5-32] d vs median, 3 [interquartile range, 2-5] d; p < 0.001) when compared with survivors. Factors significantly associated with mortality were complex chronic conditions (odds ratio, 3.29; 95% CI, 1.97-5.50), unplanned admissions (odds ratio, 5.78; 95% CI, 3.40-9.81), and admissions in spring/summer (odds ratio, 1.67; 95% CI, 1.08-2.58).

Conclusions: Nonsurvivors in the PICU with a low predicted mortality risk have recognizable risk factors including complex chronic condition and unplanned admissions.