Elevated Circulating Stromal-Derived Factor-1 Levels in Sickle Cell Disease

    loading  Checking for direct PDF access through Ovid

Abstract

Inflammation and angiogenesis are of importance in the pathophysiology of sickle cell disease (SCD). Recently, the chemokine stromal-derived factor-1 (SDF-1) has been shown to be a key mediator of angiogenesis and inflammation. In this study we determined serum SDF-1 levels in consecutive adult sickle cell patients during the clinically asymptomatic state as well as during painful crisis. Serum SDF-1 levels were significantly elevated in HbSS/HbSβ0-thalassaemia patients [n = 42; 5,177 pg/ml (2,438–7,246)] compared to HbSC/HbSβ+-thalassaemia patients [n = 16; 2,405 pg/ml (1,365–3,047)] and healthy HbAA controls [n = 45; 2,894 pg/ml (2,577–3,334)] (p = 0.001). No significant increments were observed during painful crisis (n = 40). SDF-1 levels were significantly higher in SCD patients with pulmonary hypertension (PHT) compared to patients without PHT. Elevated circulating SDF-1 levels occur in patients with SCD and may play a role in the pathophysiology of SCD-related PHT.

Related Topics

    loading  Loading Related Articles