Case Report:Molecular Genetic Analysis of a Primitive Neuroectodermal Tumor Arising after Intracranial Radiation and Chemotherapy for Leukemia

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Abstract

Abstract.

Primitive neuroectodermal tumors are aggressive tumors of the central nervous system (CNS), yet their etiology remains unclear. We report a case of a primitive neuroectodermal tumor (PNET) arising in the cerebellum and pons 7 yr after intracranial radiation and chemotherapy for leukemia involving the CNS. This case suggests a possible link between radiation, chemotherapy, and the formation of these tumors, with a potential new pathogenetic role for somatic inactivation of the protooncogene RET.

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