Increased expression of adhesion molecule CD18 (LFA-1β) on the leukocytes of peripheral blood in patients with acute ischemic stroke

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Abstract

Objectives

The aim of this study was to investigate whether adhesion molecules play a role in acute ischemic stroke.

Material and methods

Using immunofluorescence phenotyping and flow cytometry, the expression of leukocyte adhesion molecules CD54, CD11a, CD11b and CD18 in peripheral blood were measured within 12 h after onset of ischemia in 20 patients with stroke. Follow-up measurements were performed at 7 and 30 days after ictus.

Results

CD18 immunofluorescence was significantly increased on the leukocytes within 12 h after onset in patients with stroke compared with the age-matched control group (20 patients with other neurological diseases). Follow-up measurement of CD18 revealed normal results as found in the control group.

Conclusion

Our data support the idea that adhesion molecules are involved in tissue injury in ischemic stroke.

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