FcγR and multiple sclerosis: an overview

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Abstract

Receptors for the Fc domain of IgG (FcγR) play a key role in the immune system by linking the cellular and humoral immune systems. Despite extensive documentation of CNS-specific antibodies in cerebrospinal fluid and plaques in multiple sclerosis (MS) patients, the role of FcγR in this disease remains largely unexplored. Studies indicate however, that polymorphisms in some FcγR genes and treatment that induces FcγR on immune-competent cells could influence disease progression and treatment response.

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