An immunprecipitation assay for the detection of onconeural antibodies

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Abstract

Introduction

Onconeural antibodies are found in some patients with cancer, and are associated with paraneoplastic neurological syndromes.

Method

A multi-well adapted fluid-phase immunoassay using radiolabelled recombinant onconeural proteins for the detection of onconeural antibodies is described.

Result and Conclusion

This immunoprecipitation technique is more sensitive in detecting onconeural antibodies than immunohistochemistry and immune blots.

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