TNF-α, TNF-β and IL-4 gene polymorphisms in Iranian patients with multiple sclerosis

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Objective –

To investigate the association between tumor necrosis factor-α (TNF-α) G-308A, tumor necrosis factor-β (TNF-β) G+252A and interleukin-4 (IL-4) C-590T polymorphisms and susceptibility to multiple sclerosis (MS) development and clinical course of the disease.

Materials and methods –

Two hundred and seventy patients with MS and 542 sex and ethnic matched controls were enrolled in the present study. An allele-specific oligonucleotide polymerase chain reaction was used to detect the polymorphism at position −308 of the TNF-α gene. The genotypes of TNF-β and IL-4 were determined by polymerase chain reaction-restriction fragment length polymorphism.

Results –

Allelic and genotypic frequencies for these polymorphisms were similar in patients with MS and population controls or among different types of the disease.

Conclusion –

The results of the present study suggest that the three mentioned functional polymorphisms are not likely to cause susceptibility to MS in the Iranian population.

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