Baseline characteristics and vitreoretinal interface features in patients with vitreomacular traction associated with macular hole from the MIVI-TRUST clinical program

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Abstract

Purpose

There is limited published evidence on demographic and vitreoretinal interface (VRI) characteristics of patients with vitreomacular traction in association with macular hole (VMT+MH). Establishing insights into the characteristics of untreated VMT+MH may contribute to a better understanding of the burden of VMT disease To describe baseline patient characteristics and VRI features in patients with VMT+MH included in the phase 3 ocriplasmin studies

Methods

Two randomized, double-masked, placebo-controlled trials designed to determine efficacy and safety of ocriplasmin for the treatment of VMT comprising 652 patients. Key baseline characteristics included patient demographics (age, gender); eye-disorder (time since VMT diagnosis, visual acuity (VA) study eye (SE); non-study eye (NSE), pseudophakia and/or ERM); VRI features (MH width; vitreous separation), VFQ-25 composite score

Results

VMT+MH was present in 153 patients (23.5%). Baseline characteristics were: 68.7 years (SD 7.1); 75.8% female. Time since diagnosis: 62 days (SD 131); VA: SE 55.9 (SD 10.5), NSE 77.8 (SD 14.3). Pseudophakes: 20.9%, concomitant ERM: 15.8%. Min-max hole width: 272.7 (SD 127.7), vitreous adhesions attached at fovea and optic nerve (89.5%); VFQ-25 composite score: 80.3 (SD 14.6)

Conclusion

This analysis reports baseline characteristics of patients with VMT+MH, which can be used to demonstrate differences in VMT patients without MH

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