Rating circadian biorhythms of the eye-wall tension and cardiovascular system functional parameters in normal subjects(N) and patients with primary open-angle glaucoma(POAG), normal tension glaucoma(NTG), ocular hypertension(OH).Methods
Study population: 50 Ns, 30 POAGs, 10 NTGs and 7 OHs. Simultaneous, 24 hours continuous ocular tonography Triggerfish and ECG/Blood pressure Holter recordings. The comparison in 4 time intervals, set basing on time of falling asleep(F) and awakening(W). Data are compared within intervals (IN) 1:(F-5hrs,F], 2:(F,F+3], 3:(F+3,W], 4:(W,W+5]Results
Similar eye-wall tension profiles for N and OH were detected, both decreasing in IN4, OH shows higher values in IN3. POAG and NTG tension profiles are different in IN4 with noticeable change for POAG with its value increase in opposite to others. Cardiovascular parameters show the similar characteristics of SAP for all cases with the highest value for OH and the lowest for N. The recordings for DAP show the noticeable difference for NTG, where the profile is changing rapidly between the highest values in INs2 and 4 to the lowest one in IN3. Additionally, only for OH the IN3 value is higher than IN4 one. The comparison of heart rate profile shows a noticeable difference for POAG. All data will be presentedConclusion
The study showed specific, group dependent, biorhythms for 24-hour circadian eye-wall tension and functional parameters of cardiovascular system. These figures bring new insights into the pathogenesis of glaucomatous neuropathy and indicate the location of potential handle points for individual time-dependent therapeutic options.