Pseudoexfoliation: normative data and associations. The Central India Eye and Medical Study

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Abstract

Purpose

To assess the prevalence of pseudoexfoliation (PEX) and its associations in a population-based setting.

Methods

The population-based Central India Eye and Medical Study included 4711 individuals. All study participants underwent a detailed ophthalmological examination. After medical pupil dilation, PEX was assessed by an experienced ophthalmologist using slit-lamp based biomicroscopy.

Results

PEX was detected in 87 eyes (prevalence: 0.95±0.10% (95%CI:0.75,1.15) of 69 subjects (prevalence: 1.49±0.18% (95%CI:1.14,1.83). In multivariate analysis, PEX prevalence was associated with higher age (P<0.001; OR:1.11), lower body mass index (P=0.001) and higher diastolic blood pressure (P=0.002). In the multivariate analysis, PEX was not associated with retinal nerve fiber layer cross section area (P=0.76) and presence of open-angle glaucoma (P=0.15). Side differences in the presence of PEX were not significantly associated with side differences in intraocular pressure (P=0.40).

Conclusion

In a rural Central Indian population aged 30+ years, PEX prevalence (mean: 1.49±0.18%) was significantly associated with older age, lower body mass index and higher diastolic blood pressure. It was not significantly associated with optic nerve head measurements, refractive error, any ocular biometric parameter, nuclear cataract, early age-related macular degeneration and retinal vein occlusion, diabetes mellitus, smoking, and dyslipidemia.

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