High resolution retinal image analysis of unilateral retinitis pigmentosa using adptive optics

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To report the findings of en face adaptive optics (AO) fundus imaging in eyes with unilateral retinitis pigmentosa(RP) patient.


The both eyes from a unilateral RP patient, 52 y.o. female, was imaged using both an infrared AO camera (rtx1™, Imagine Eyes, France) and spectral-domain optical coherence tomography (SD-OCT – Cirrus™, Carl Zeiss Meditec, Germany). Full field scotopic and phototic electroretinograms(ERGs) were recorded according to the ISCEV standard. Normal funduscopic examination, Goldmann visual field and fluorescence angiography(FA) were also examined. The AO images acquired from the unilateral RP patient were analyzed on cone density and then compared to the AO data from the eyes of 21 healthy volunteers with a mean age of 36 years (range 20-57).


The unilateral RP patient showed boney spicule changes, vascular attenuation and decreased peripheral visual field in the right eye. FA showed granular hyperfluorescence in the post pole, mottling of RPE and atrophy of choroid capillary in the peripheral retina in the right eye. Her ERGs of the right eye showed non-recordable in all responses tested. OCT findings in the right eye showed preservation of the photoreceptor layer only in the foveal and parafoveal regions with loss in the more peripheral macula. All these results in her left eye were normal. AO data showed severe reduction of cone density in the right eye and the left eye showed normal cone density and regular cone mosaic.


In unilateral RP patient, AO showed only one eye was affected even in the cellular level examination. The examinations using AO may be useful in diagnosis and better understanding of pathology and management of unilateral RP cases.

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