Congenital hypertrophy of the Retinal Pigment Epithelium (CHRPE) is a tumour which may be confused with pigmented tumours of the choroid such as nevi or melanomas. These lesions are round or oval shaped, with borders that are well defined or scalloped. They present areas of atrophy which may increase in size. This increase in size of CHRPE is well documented and innocent. However, transformation in adenomas or even adenocarcinomas is also possible. In consequence, a periodical observation for Congenital hypertrophy of the Retinal Pigment Epithelium is generally recommended.