Evaluation of ultra-widefield fundusautofluorescence in non-infectious posterior uveitis

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Posterior uveitis comprises a heterogenous group of diseases with inflammatory alterations of the posterior fundus and is a common cause of visual impairment and blindness. The goal of this study is to evaluate the diagnostic value of wide-field-fundusautofluorescence (FAF) of patients with non-infectious posterior uveitis and chorioretinal alterations.


73 eyes from 51 patients were included. Best-corrected visual acuity, wide-field color and FAF images achieved by a wide-field SLO (Optomap P200Tx, Optos PLC, Dunfermline, Fife, Scotland, UK) and a full ophthalmological examination were obtained from each patient. A systematic analysis of chorioretinal alterations detected with FAF and color images was conducted followed by the evaluation of the diagnostic information of wide-field FAF compared to the clinical finding and wide-field color images respectively.


52 of 73 included cases showed peripheral alterations. In 32 cases, wide-field FAF images revealed a greater number and more extended chorioretinal alterations than corresponding wide-field color images of the posterior fundus.


In this study, wide-field FAF images showed more chorioretinal alterations than seen in funduscopy or in color SLO images. Therefore, wide-field FAF images offer important additional information in detection and documentation of peripheral and central chorioretinal alterations.

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