Mechanism of fluid accumulation

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Abstract

Purpose:

To characterise the cellular mechanisms of fluid flow in the retina in view of its clinical implications.

Background:

Retinal fluid homeostasis is effected by a whole host of mechanisms that reside both in the retinal pigement epithelium, in the choroid and in the retina. In a physiological state there is a constant flow of fluid out of the intraretinal and subretinal space into the choroid, of which about 70% is effected via active transport mechanisms within in the retinal pigment epithelium.

In case these Results:

This presentation will summarise the latest data on how fluid homeostasis is maintained within the retina and how these mechanisms underly the evolving phramacological treatment modalities for exudative maculopathies.

Conclusion:

The understanding of the cellular mechanisms that govern retinal fluid flow is crucial to the cinical application of medical treatments against exudative maculopathies.

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