We have developed a drug delivery platform based on cyclodextrin nanoparticles in eye drop suspensions. The nanoparticles increase drug solubility, extend mucoadhesion and penetration into the eye. High concentrations of drug in the tear film for extended periods of time allow for greatly increased penetration into the eye and relatively less washing into the nasolacrimal apparatus. Dexamethasone nanoparticle eye drops are effective against diabetic macular edema and uveitis. Cyclodextrin nanoparticle eye drops allow drug treatment of retinal disease with eye drops.