Intraarterial chemotherapy: Indications and results

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IA chemotherapy is a promising primary and salvage treatment for moderate and advanced RB particularly in eyes designed for enucleation. Indications include: Primary treatment of unilateral retinoblastoma Reese-Ellsworth Stage II, III, IV, Va & Vb (ABC Stage B, C & D); adjunctive treatment after systemic chemotherapy, with or without focal therapy; incomplete response to conservative therapy; local tumor recurrence after conservative therapy. Most of adverse side effects are transient, choroidal vasculopathy is permament and in some cases progressive. Intra-arterial chemotherapy conserves many eyes with retinoblastoma that would otherwise require enucleation, at the same time avoiding the risks of radiotherapy and systemic chemotherapy.

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