The treatment of bilaterally advanced retinoblastoma: The Institut Curie experience

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Since 2005 we have used more intensive chemotherapy, combined with intensive local treatment started at the third cycle in case of bilateral group D or group D+E bilateral retinoblastoma. We report the results


All children identified with bilaterally advanced retinoblastoma were treated with 6 courses of 3 drugs. Local treatments including laser, cryotherapy and sometimes iodine plaque brachytherapy were started at the third cycle, synergistic with the chemotherapy. All tumors except the macular tumors were treated with laser during 5 to 20 minutes. The inferior periphery was treated with cryotherapy. After the end of the chemotherapy, close follow up was performed and additional local treatments were often necessary. Data concerning the initial findings, treatments and results were entered in the data base.


the follow up ranges from 3 to 8 years with a mean follow up of five years. Between 2005 and 2010 23 group D eyes were treated in 16 children.17 eyes are preserved without external beam (73%) One eye is lost to follow up. Visual acuity is available in 11 children ranging from counting fingers to 20/20 with a mean visual acuity of 20/50.


Intravenous chemotherapy associated with intensive local treatments allows preservation of the eye with usefull vision in a great pourcentage of group D eyes.

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