Macular choroidal thickness profile in healthy population measured by swept-source optical coherence tomography

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Abstract

Purpose

To determine choroidal thickness (CT) profile in healthy population by swept-source longer-wavelength optical coherence tomography (SS-OCT).

Methods

Cross-sectional, non-interventional study. The macular area of 276 eyes, from 154 healthy patients was studied with an SS-OCT prototype system. A horizontal CT profile of the macula was created by manually measuring subfoveal CT (SFCT, from the posterior edge of retinal pigment epithelium to the choroid/sclera junction). Three further determinations were performed every 1000 μm nasal to the fovea and five more every 1000 μm temporal to the fovea. CT was independently determined by two observers.

Results

SS-OCT allowed visualization of CT in all cases (100%). Mean SFCT was 301.89±80.53 μm (95% confidence interval: 292.34 to 311.43). Mean horizontal macular CT (MCT) was 258.69±64.59μm (95% confidence interval: 251.04 to 266.35). Mean SFCT was 325.6±51.1 μm in 0 to 10 years, 316.7±90.1 μm in 11 to 20 years, 313.9±80.3 μm in 21 to 40 years, 264.6±79.3 μm in 41 to 60 years and 276.3±88.8 μm in more than 60 years (P<0.001; Anova test). Mean horizontal MCT was 286.0±43.5 μm, 277.7±68.2 μm, 264.0±61.9 μm, 223.4±62.2 μm and 229.7±66.1 μm for 0 to 10, 11 to 20, 21 to 40, 41 to 60 and > 60 years respectively (P<0.001; Anova test). The CT profile was different for each age group.

Conclusion

Macular CT profile in healthy population is similar between different age groups with thicker CT in young people.

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