Choroidal thickness in dry age-related macular degeneration

    loading  Checking for direct PDF access through Ovid

Abstract

Purpose

To compare the choroidal thickness (CT) in the macular area in eyes with nonexudative age-related macular degeneration (AMD) with that of unaffected fellow eyes and eyes of healthy controls.

Methods

Enhanced depth imaging (EDI) was obtained by spectral-domain optical coherence tomography (SD-OCT) (Spectralis, Heidelberg-Engineering, Germany) in 47 eyes of 52 patients (78.7 ± 7.1 years) with AMD, 96 eyes of 96 healthy controls (74.0 ± 8.5 years) and in 5 unaffected contralateral eyes (68.6 ± 14.4 years). Eyes were divided into 3 groups: 47 eyes in group A (affected eyes with AMD), 5 eyes in group B (unaffected fellow eyes), and 96 eyes in group C (right eyes of age-matched controls). Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid-scleral junction in the subfoveal area (SCT) and 1 mm away from the fovea in the nasal (NCT) and temporal (TCT) regions. Statistical analysis was conducted to compare mean choroidal thicknesses.

Results

In the AMD group the mean choroidal thicknesses were 164.9 ± 62.4 μm at the fovea (SCT), 150.7 ± 64.8 μm nasally (NCT), and 171.1 ± 63.3 μm temporally (TCT). In the unafected fellow eyes these measurements were 219.2 ± 143 μm, 215.8 ± 129.1 μm, and 226.2 ± 113 μm, respectively. Finally, the control group showed the following values: 234.9 ± 100.4 μm, 224.7± 96.4 μm, and 233.0 ± 95.5 μm, respectively. Choroidal thickness did not show any statistically significant differences among the three groups of eyes when age was counted as a confounding variable (p>0.05, ANOVA test).

Conclusion

There were no significant differences between choroidal thickness of nonexudative age-related macular degeneration with the contralateral unaffected eye or the control group.

Related Topics

    loading  Loading Related Articles