Choroidal thickness measurement in children using optical coherence tomography

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Abstract

Purpose

To measure choroidal thickness in children of various ages by using spectral optical coherence Tomography with enhanced depth imaging (EDI). The primary outcome was to measure choroidal thickness in children. The secondary outcomes were to investigate the association between subfoveal choroidal thickness and ocular axial length, age, gender, weight, and height in children.

Methods

Hospital-based cross-sectional study. Healthy children visiting at the University Hospital of Besançon were prospectively included between May and August 2012. Optical coherence tomography with the EDI system (Spectralis®, Heidelberg, Germany) was used for choroidal imaging at nine defined points of the macula of both eyes. Axial length was measured by using IOL Master® (Carl Zeiss. Meditec. USA). Height, weight and refraction were recorded.

Results

Three hundred forty height eyes from 174 children were imaged. The mean age of the children studied was 8.70±2.89 years (mean±SD); range 3.5-14.9 years. The mean subfoveal choroidal thickness in right eyes was 341.96±74.7 μm. Mean axial length was 22.30±1.05mm. Choroidal thickness increased with age (r=0.24, p=0.017), height and weight but not with sex (p>0.05). It was also inversely correlated to axial length (r=0.24, p=0.001). There was a moderate correlation between the two eyes in terms of choroidal thickness (r=0.6). The nasal choroid appeared thinner than in the temporal area (ANOVA, p<0.0001)

Conclusion

In children, choroidal thickness increases with age and is inversely correlated to the axial length. There is a significant variation of the choroidal thickness between children of the same age.

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