Visual evoked potentials, short wave-length automated perimetry, standard automated perimetry, contrast sensitivity and stereoacuity testing in visually asymptomatic eyes of patients with multiple sclerosis

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To evaluate the efficacy of PVEP, standard automated perimetry, short-wavelength automated perimetry, CS, stereoacuity in detecting subclinical visual impairment in patients with multiple sclerosis (MS) and no history of optic neuritis.


Twenty-seven MS patients (average age 33.81±9.33 years) underwent PVEP with 60 and 15-minute arc check sizes, SAP (Humphrey 750-II, SITA standard strategy), SWAP (program central 30-2), CS, Stereoacuity by RSA test. They were age and sex matched with twenty seven normal subjects.


Stereoacuity was significantly reduced in MS group compared with controls. (p=0.007). P100 latency time for both check sizes was significantly prolonged in MS group compared with controls (p=0.005). P100 amplitude significantly reduced in MS group compared with controls (p<0.001). When comparing MS patients with the control group significant differences were found for SAP MD, SWAP MD, SAP PSD, SWAP PSD (p<0.001). By considering predefined criteria, asymptomatic MS patients have shown abnormal stereoacuity in 22.2%, abnormal VEP in 40.7%, abnormal CS in 37%, abnormal SAP in 44% and abnormal SWAP in 37% of patients.


Our results concluded the probable presence of subclinical visual impairment among MS patients without optic neuritis history and no visual symptoms. The Pattern VEP and perimetry test together are useful choices in the regular assessment of these patients.

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