The regulatory effects of 1, α, 25-dihydroxyvitamin D3 on the expression of inflammatory cytokines in diabetic retinopathy

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Abstract

Purpose

Diabetic retinopathy (DR) is typically characterized by abnormal changes in the microstructure of retina as a result of prolonged uncontrolled diabetes mellitus. Several mechanisms on how high glucose concentration alters retina microvasculature have been proposed. One of these mechanisms is the activation of alternative glucose pathways leading to accumulation of several metabolic end-products which induce oxidative stress in retina causing cellular changes of the expression of pro and inflammatory mediators. Thus, the aim of this study is to investigate the protective function of vitamin D in diabetic retinopathy

Methods

1-Treatment of ARPE-19 cell line with the active form of vitamin D 2-Diabetic animal models are induced for type 1 diabetes mellitus and treated with calcitriol

Results

1-Vitamin D down-regulates the expression of pro and inflammatory cytokines involved in DR 2-It up-regulates the expression of antioxidative stress scavengers 3-Vitamin D improves cell survival during inflammatory process

Conclusion

Changes in the expression patterns of immunomodulatory and antioxidative proteins after vitamin D treatment propose a protective function of vitamin D in DR

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