Clinical characteristics of acute retinal pigment epitheliitis: Case series

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To describe characteristics of acute retinal pigment epitheliitis by analyzing 16 cases.


Retrospective chart review of patient diagnosed with acute retinal pigment epitheliitis was done. Medical records, fundus photo, optical coherence tomographic(OCT) findings and fluorescein angiographic(FAG) findings were reviewed.


The average age at diagnosis was 39.6 year-old, with male to female ratio of 2:1. Acute metamorphopsia or central scotoma with slight decreased vision were chief complaints, and the symptoms resolved spontaneously after 60.1 days. Funduscopic finding revealed macular mottling with surrounding yellow hypopigmented areas, with subsensory retinal detachment in some cases. Disruption of the photoreceptors’ inner segment and outer segment interface with hyperreflection at retinal pigment epithelial(RPE) level were found in OCT. On FAG, window defect was seen. Retinal pigment epithelial changes remained after resolution of symptoms in all cases.


Acute retinal pigment epithelitiis is an infrequent macular disorder in young adults with symptoms of metamophopsia or central scotoma and signs of RPE change with window defect on FAG. Differential diagnosis is important beause of the good prognosis without treatment.

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