Ganglion cell complex measurement and glaucoma diagnosis using two SD-OCT

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Macular retinal ganglion cell analysis from Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) and RTVue-OCT (Optovue Inc., Fremont, USA) were evaluated in their glaucoma diagnostic ability.


A total of 169 eyes were enrolled in 3 groups: (1) 70 early primary open angle glaucoma patients (POAG), (2) 44 moderate-to-advanced POAG, (3) 55 normal subjects. All patients underwent a complete examination and a macular analysis using GCA algorithm from Cirrus HD and GCC algorithm from RTVue. Macular average, minimum and 6 sectoral GCL-IPL thicknesses obtained with Cirrus and average, inferior and superior GCC thicknesses and FLV and GLV obtained with RTVue were analyzed. Each eye underwent cpRNFL analysis using Cirrus and RTVue. Glaucoma discrimination ability was assessed using area under the receiver operator characteristic curve (AUC) for all parameters.


Average GCL-IPL thickness with Cirrus was 65.6 ± 7.4 μm, 57.8 ± 13.1 μm and 80.3 ± 9.9 μm and average GCC with RTVue was 75.7 ± 10.7 μm, 72.6 ± 9.7 μm et 93.9 ± 7.7 μm, for group 1, 2 and 3 respectively (p<0.05 between each group). AUCs ranged from 0.836 to 0.925 for Cirrus macular parameters and from 0.878 to 0.949 for RTVue macular parameters. These values were compared to the discrimination ability of cpRNFL parameters from each OCT.


The two OCT macular ganglion cell analysis showed similar glaucoma diagnostic ability and were comparable with that of cpRNFL. Specific macular parameters: GCL-IPL minimum, GCL-IPL inferotemporal, FLV and GLV have a high diagnosis performance.

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