Choroidal thickness in open-angle glaucoma

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Abstract

Purpose

To examine choroidal thickness in open-angle glaucoma in a hospital-based case series study

Methods

Choroidal thickness was measured by enhanced depth imaging of spectral domain optical coherence tomography. The study group included patients with open-angle glaucoma and the control group consisted of subjects with a normal fundus.

Results

The study group included 71 eyes (39 patients) and the control group consisted of 189 patients (228 eyes) with significant difference between both groups in age (P=0.16) and refractive error (P=0.07). Choroidal thickness in the foveal region (P=0.18), at a distance of 1000 μm from the fovea (P=0.39), at a distance of 2000 μm from the fovea (P=0.46), and at a horizontal distance of 2500 μm from the fovea (P=0.53) did not vary significantly between both groups. In multivariable analysis with adjustment for age and refractive error, subfoveal choroidal thickness (P=0.12; regression coefficient B: -8.60; 95%CI: -19.3, 2.1), choroidal thickness at a horizontal distance of 1000 μm from the fovea (P=0.30; B: -4.98 (95%CI: -14.3, 4.4)), 2000 μm from the fovea (P=0.20; B: -20.9 (95%CI: -53.2, 11.3)) and 2500 μm from the fovea (P=0.45; B: -2.70 (95%CI: -9.67, 4.27)) was not significantly associated with the diagnosis of glaucoma. In binary regression analysis with adjustment for age and refractive error, presence of glaucoma was significantly associated neither with subfoveal choroidal thickness (P=0.12; OR: 0.997 (95%CI: 0.993, 1.001)), nor with choroidal thickness at a horizontal distance of 1000 μm from the fovea (P=0.47; OR: 0.998 (95%CI: 0.993, 1.002)).

Conclusion

After adjusting for age and refractive error, open-angle glaucoma was not significantly associated with a marked thinning or a thickening of the choroid in the foveal and parafoveal region.

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