Ocular morphology and visual function in relation to general growth in moderate-to-late preterm school-aged children

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Abstract

Purpose:

To study ocular morphology and visual function in relation to general growth in moderate-to-late preterm (MLP) children.

Methods:

Visual acuity (VA), refraction, optic disc parameters, biometric values and anthropometric measures were obtained from 50 eight-year-old MLP and 43 full-term children. Macular parameters were examined by optical coherence tomography. Serum insulin-like growth factor I (IGF-I) levels were analysed at birth and at assessment and delta IGF-I was calculated.

Results:

Total macular volume was significantly less in MLP than in controls (both eyes p < 0.01). Macular volume correlated with head circumference (HCF) at assessment [right eye (RE) p = 0.002,r= 0.67; left eyes (LE) p = 0.01,r= 0.54] and refraction (both eyes p < 0.05,r= 0.4) in the MLP children. Furthermore, central retinal thickness correlated significantly with delta IGF-I (RE p = 0.03,r= −0.51, LE p = 0.006,r= −0.59) and refraction (both eyes p < 0.01,r= 0.5) and optic disc areas correlated with weight and height at assessment (all p < 0.05,r= 0.4). Total axial length correlated with HCF at assessment (both eyes p < 0.01,r= 0.5) and VA logMAR (both eyes p < 0.02,r= −0.4).

Conclusions:

Macular volume was significantly less in MLP children than in controls examined at 8 years of age. General growth of children and IGF-I levels seem to be involved in development of ocular growth and morphology.

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