logo
Deciphering the functional role of hippocampal synaptic plasticity in learning and memory
No time to lose: Epo regulation in high-altitude
How to inhibit seizures?
Tubuloglomerular Feedback
Molecular identity and properties of the volume-regulated anion channel VRAC
Kv1.1 channels - from episodic ataxia to gene therapy for epilepsy
Function and modulation of TRP channels in the somatosensory system
Cell-specific regulation of calcium ion channel function
L-type calcium channels in brain disorders
Electrical signaling in sperm - exotic ion channels with weird properties
Optogenetics: Lighting up the brain
Long non-coding RNAs in the control of the endothelial phenotype
The soluble epoxide hydrolase attenuates pathological vascularization by preventing astrocytes loss in retinopathy of prematurity in mice
Von Willebrand factor-platelet string-mediated endothelial cell-leukocyte interaction in maladaptive vascular remodelling processes
New insights into vessel remodeling by angiotensin - role of the endothelium
Not just for contraction: Emerging roles for regulator of G-protein signaling 5 in orchestrating vascular smooth muscle cell activity
Comparing phosphodiesterase-dependent cardiovascular and gastrointestinal smooth muscle relaxation
Nanomedicine: Vascular repair by circumferential gene and endothelial cell therapy
Echocardiography
PET & SPECT: Cardiovascular molecular imaging
Cardiovascular magnetic resonance in mice: beyond vasculature and cardiac function
Generation and characterization of cardiomyocyte-specific redox sensor mouse lines
New aspects of proteinuria: insights from multiphoton microscopy
mTOR complexes - segment specific regulators of tubular transport
Role of proteolytic activation of ENaC in hypertension with albuminuria
Diuretic-induced changes in urinary acid and base excretion
Doing the Graveyard Waltz - Balancing regulated necrosis in AKI
TRPC1/4/5 channels in health and disease
Role of the kinase-coupled TRPM6 channel in magnesium homeostasis: From mouse models to human disease
Regulation of TRPM3 activity in somatosensory neurons by opioid substances
A TRP channel CAN CAN that regulates Ca2+ dependent cell functions
TRPM4 channel in cardiac electrical disorders
Regulation of aldosterone release by potassium
Dietary potassium and the renal control of salt balance and blood pressure
Disturbances of potassium homeostasis: a clinical perspective
Potassium and cardiac arrhythmias
ROMK in proteinuria, data from rat and human kidney
Functional role of metabotropic group I glutamate receptors in synaptic plasticity at granule cell - Interneuron synapses
Structural plasticity of parvalbumin-expressing cells in the dentate gyrus
Differential GABAB receptor-mediated control of inhibitory interneuron types in hippocampal networks
Activity-dependent regulations of interneuron circuits
Sensorimotor transformation in the mouse forepaw system
Non-associative potentiation of perisomatic inhibition
Neocortical somatostatin neurons reversibly silence excitatory transmission via GABAb receptors
Mitochondrial function during exercise
Weak by the machines - skeletal muscle as target in critical conditions
Myokine signaling during inflammation and aging
Immune modulation by exercise in tumor patients - role of the muscle
Ethics and animal experiments
Lurking in the shadows: how animal facilities and experimental practices affect your research
Carrying out procedures on animals: “Adequately educated and trained before (Art. 23 EU directive 2010/63)”? Theory and practice in legislation and animal research
Erythropoiesis and hemoglobin function: Impact on adaptation to hypoxia
Formation of neutrophil and mast cell extracellular traps under low oxygen level
Hypoxia-inducible factor 1 determines dendritic cell function in colitis
Prolyl-4-hydroxylase domain (PHD) is a critical terminator for cell survival of macrophages under stress conditions
Molecular mechanism of neuropeptide transport and release in hippocampal neurons
The role of brain-derived neurotrophic factor secretion in spike timing-dependent synaptic plasticity
Molecular mechanisms of surfactant release in the post-fusion phase of exocytosis
The acrosome reaction in sperm: A special type of regulated exocytosis mediated by the SNARE fusion machinery
Insulin granule biogenesis and turnover
Chemical biology of H2S signaling
Hypoxic preconditioning-like effects caused by the combined application of H2S and nitrite protect the cells from the hypoxia/reoxygenation-induced cell death
Role of H2S in the cardiovascular system
Role of Cystathione γ-Lyase in acute ischemic kidney injury
H2S and Renal (Dys)Function. PDGF: the paradigm growth factor that orchestrates the crosstalk of gasotransmitters in the kidney
H2S and homocysteine; new insights from two hyperhomocysteinemic mutant mouse strains that lack H2S-generating enzymes
Sodium Channels of stem cell derived human nociceptors - potentials and pitfalls
PIEZO2 is required for mechanotransduction in human ES-cell-derived touch receptors
Modelling neuropsychiatric diseases using human induced stem cell-derived neurons
How human motor neurons get sick: Disease modeling of motor neuron degeneration using hIPSCs
Optogenetic manipulation of intracellular signaling cascades in cardiomyocytes
Inseparable: Cellular electrophysiology and intracellular calcium in cardiac myocytes
Photopharmacological tools to control cellular function with light
Determination of oxygen consumption rates during network oscillations with Clark-type oxygen microsensors
Influence of auxiliary subunits on AMPAR function in hippocampus and thalamus
Besides its effect on bladder contractility, caldesmon deficiency leads to a triad of morphological features: umbilical hernia, split lower part of the sternum and white liver areas
c-Src tyrosine kinase contribution to 5-HT-mediated contraction in rat skeletal muscle arteries is Ca-dependent
Arterial stiffness and pulse wave velocity in mice lacking NO-sensitive guanylyl cyclase
The role of alternative mRNA splicing and threonine 696/853-phosphorylation of myosin phosphatase regulatory subunit (MYPT1) in the regulation of tone of murine brain vasculature
Consequences of postnatal vascular smooth muscle EGF-receptor deletion on acute angiotensin II action
Aging-related progressive skeletal muscle weakness in mutant DesR349P muscles: a matter of compromised cytoarchitecture
Comparing phosphodiesterase-dependent cardiovascular and gastrointestinal smooth muscle relaxation
An extra kick from the giant muscle protein titin
C-type- not atrial- natriuretic peptide stabilizes mast cells and attenuates microvascular leakage during ischemic reperfusion
Contribution of myogenic response to peripheral vasoconstriction during orthostatic challenge
The oxygen sensor PHD2 affects cell migration, energy metabolism and mitochondrial function in macrophages
Hypoxia-induced myeloid cell function through hypoxia inducible factor 1 impairs the clinical course of experimental inflammatory bowel disease
Characterisation of the SDS-PAGE resistant protein:protein heterodimer FIH:OTUB1 - Implications for oxygen sensing?
Prolyl-4-hydroxylase domain enzymes 2 and 3 differentially regulate the inflammatory response in a murine model of hind limb ischemia
Inhibition of the nucleotide pool sanitizing enzyme MTH1 augments genotoxic effects of ionizing radiation and hypoxia on tumor cells
Estrogen-dependent downregulation of hypoxia-inducible factor (HIF)-2α in invasive breast cancer cells
Controlling the gates by nuclear import receptors: Targeting nuclear transport affects HIF-dependent hypoxia response
The transcription factor WT1 regulates gonadal expression of the receptor for vascular endothelial growth factor A (KDR, VEGFR2) in a sex-specific manner
Conduction disorder caused by a mutation in POPDC2 , a novel modulator of the cardiac sodium channel SCN5A
Deletion of the TRPV4 cation channel in mice does not cause marked changes of skeletal muscle structure: a comparison with dystrophic mdx mice
Role of TRPC1 channels in pressure-mediated activation of murine pancreatic stellate cells
The bovine analogue of TRPV3 conducts the NH4+ ion
The photosensitization by 7-dehydrocholesterol activates TRPA1 and TRPV1 - connections to the Smith-Lemli-Opitz syndrome
A forward genetic screen identifies a Ca2+-regulated mitochondrial metabolite carrier required for the establishment of left-right asymmetry
Differential control of intracellular Ca2+ signaling by anoctamins
Differential accessibility to phospholipase C defines functional PI(4,5)P2 microdomains in the plasma membrane
FRS1l is a central determinant of AMPA-receptor biogenesis and linked to severe intellectual disability
3D super-resolution mapping of synaptic proteins in brain tissue
Single action potentials trigger fast and clathrin-independent endocytosis at a central synapse
Dysfunction of thalamo-amygdala circuits and up-regulated TrkB/ERK-MAPK signaling leads to obsessive-compulsive-like behavior in SPRED2 KO mice
Coordination of innate behaviours by GABAergic cells in lateral hypothalamus
Dendritic integration in Dentate Gyrus parvalbumin-expressing perisoma-inhibiting interneurons
Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics
Molecular architecture of parallel fibre-to-Purkinje cell active zones elucidated by d STORM
Vascular endothelial growth factor receptor inhibition upregulates renal epithelial sodium channel
Inflammation triggers FGF23 expression in kidneys of chronic kidney disease mouse models
Inhibition of endogenous proteases prevents epithelial sodium channel (ENaC) activation by aldosterone in mCCDcl1 mouse renal cortical collecting duct cells
Natriuretic peptides exert marked renoprotective effects via guanylyl cyclase-A dependent suppression of TRPC6 in podocytes
Distribution, interaction and function of claudins in the thick ascending limb of Henle's loop
The Atp6ap2/(Pro)-renin receptor is involved in Receptor Mediated Endocytosis by the Renal Proximal Tubule
The tubular renin system contributes to high circulating prorenin levels and the development of albuminuria in diabetes mellitus
Unfolding paradigm: A spring-like multi-layered protein scaffold to maintain the interpodocyte slit of glomerular podocytes
Uridine triphosphate thio analogues as P2Y12 receptor antagonists and inhibitors of platelet aggregation
von Willebrand factor mediated platelet string formation and leukocyte extravasation in the microcirculation in vivo
Notch signaling and VEGF determine a balanced VE-cadherin dynamics during angiogenesis via endothelial shape change
Deletion of the AMPKα1 subunit in endothelial cells impairs angiogenesis and endothelial migration
Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells and vascular calcification by homoarginine
RhoA ambivalently controls prominent myofibroblast characteristics by involving distinct signaling routes
p38MAPKα is protective in the early phase of cardiac remodeling in response to pressure overload
Involvement of vascular aldosterone synthase in phosphate-induced osteo-/chondrogenic signaling and calcification of vascular smooth muscle cells
Mosaic mitochondrial respiratory chain deficiency causes cardiac arrhythmia during ageing
Functional imbalance among individual cardiomyocytes caused by cell-to-cell variation in mutant mRNA expression. Random burst-like transcription as a possible trigger for Hypertrophic Cardiomyopathy
The troponin I mutation ΔK184 blunts the effects of PKA-mediated phosphorylation on contraction and relaxation kinetics but not on Ca2+-sensitivity
Contractile function of myofibrils within human embryonic stem cell-derived cardiomyocytes with known cardiac myosin isoform composition using a novel micromechanical approach
Modulation of Ca2+-regulatory function by three novel mutations in TNNI3 associated with severe infant restrictive cardiomyopathy
Long-term inhibition of AP-1 by JDP2 overexpression provokes cardiac dysfunction
Epicardium-derived cells as source of pro-inflammatory and pro-fibrotic cytokines after myocardial infarction
Generation of highly pure physiologically and pharmacologically functional Sinus-Nodal-Bodies from Pluripotent Stem Cells
Characterization of renal erythropoietin producing cells in vivo
Organ specificity of in vivo erythropoietin expression by PDGF-receptor β bearing cells
Anti-oxidative role of cytoglobin in podocytes: potential association with chronic kidney disease?
Role of the hypoxia-inducible factor pathway in cardiovascular system development in zebrafish
Hydrogen peroxide derived from the NADPH oxidase Nox4 is required for endothelial cells differentiation
Dexamethasone promotes pulmonary vascular remodeling by activation of the NOX-HIF-1alpha axis
The pharmacological Gq inhibitor FR900359 induces airway relaxation without systemic side effects
Contribution of the gasotransmitter hydrogen sulfide to hypoxic inhibition of pulmonary transepithelial sodium absorption
A skilled forelimb motor task to investigate how noradrenaline shapes cortical motor control
Delta oscillations organize prefrontal network activity during wakefulness
Adenosine-mediated modulation of olfactory bulb network activity and odour information processing
Spinal Tumor Necrosis Factor-α generates spinal hyperexcitability by recruiting spinal Interleukin-6 trans-signaling
TRPA1-mediated pain in human subjects
Achaete-scute homolog 1 determines the differentiation fate of neuroblastoma cells
Food intake and energy turnover - time of day makes a difference
Light-induced pain in porphyrias and photodynamic therapy involves TRPA1 and TRPV1
Functional ENaC inhibition induces endocytosis of the channel
Cono-RFamide from Conus textile targets Acid-Sensing Ion Channel 3 (ASIC3)
The degenerin region of the human bile acid sensitive ion channel is involved in channel inhibition by calcium and activation by bile acids
The interplay between ion channels of the Degenerin / Epithelial Sodium Channel family and the lipid bilayer
The phosphorylation site T613 in the β-subunit of rat epithelial Na+ channel (ENaC) modulates channel inhibition by Nedd4–2
Connexin 30 inhibits human epithelial sodium channel (ENaC) expressed in Xenopus laevis oocytes by reducing channel surface expression
The rapid membrane insertion of the endothelial sodium channel is induced by shear stress and stiffens the cell cortex
Regulatory role of the intracellular domain of the bile acid-sensitive ion channel (BASIC)
Altered time-frequency characteristics and aberrant cerebral excitability in the APPswe/PS1dE9 and 5XFAD model of Alzheimer's disease
Porcupine controls hippocampal AMPAR levels, composition and synaptic transmission
Intracellular pH distribution in cultured hippocampal astrocytes between somata and processes
Frequency-selective entrainment of lateral septum by hippocampal oscillations mediates top-down control of locomotion
Optimal synaptic integration windows in the range of highfrequency oscillations through the instantaneous time constant
Hyperpolarization-activated currents facilitate high-frequency action potential firing in cerebellar mossy fibers
Variable topography of pre- and postsynaptic proteins in the hippocampal mossy fibre tract
Lobule- and layer-specific frequency dispersion in the cerebellar cortex
Distinct stimulus dependent dilatory mechanisms in the murine coronary vascular bed: NO and Cx40-dependent coupling during reactive hyperemia, but prostaglandins upon ACh
Functional inhibition of ENaC alters the cortical cytoskeleton
Supramolecular organization of junction associated intermittent lamellipodia (JAIL) in vivo
Adenosine receptors regulate gap junction coupling in endothelial cells by different pathways
Long-term exposure to shear stress stimulates endothelial glycocalyx recovery
Reduced NO sensitivity in arterioles deficient for the soluble guanylyl cyclase alpha 1 subunit in vivo
Endothelial cell labeling and magnet-assisted purification using a transgenic PECAM/eGFP mouse model
EPLIN isoforms differentially control adherens junction dynamics in endothelial cells
The ammonia transporter RhCG modulates vacuolar H+-ATPase function in renal collecting duct cells
Role of the organic cation transporter 2 in nephro- and neurotoxicity mediated by chronic treatment with cisplatin
Dynamics of melanoma cell-cell interaction depending on Na+/H+ exchanger 1 expression and pericellular pH
Lactate contributes to fast recovery of activity dependent ion concentration changes in rat CA3 hippocampus
Hypoxia-induced carbonic anhydrase IX facilitates lactate transport in human breast cancer cells by non-catalytic interaction
Digestion physiology predicts sensitivity to CO2-driven seawater acidification in non-calcifying marine larvae
Clathrin coat assembly inhibitor disassembles the nuclear pore: Implications for physiology and gene therapy
OGR1 is involved in acid-induced hypercalciuria
Cerulean: A genetically encoded fluorescent protein for monitoring real-time acidification of glutamatergic synaptic vesicles with multiphoton fluorescence lifetime imaging microscopy
The SNAP-25 linker is an integral regulator of SNARE-mediated exocytosis
A potential presynaptic role of Glra3 in regulation of glycinergic synaptic inhibition to hypoglossal motoneurons
Investigation of presynaptic plasticity at hippocampal mossy fiber active zones using structured illumination microscopy
Searching for vesicular/cytoplasmic binding partners of the presynaptic active zone protein Bruchpilot in vivo
Molecular mechanism of large dense core vesicle dead-end docking in mouse chromaffin cells
Cisplatin-induced neuropathic pain is mediated by N-type voltage-gated calcium channels
Optimization of stem cell culture conditions for maintenance and differentiation into peripheral neurons
Characterization of rat spinal dorsal horn neurons responsive to laser-induced heat stimulation of the skin
Oxaliplatin modulates subtypes of voltage-gated calcium channel currents in small DRG neurons
Cinnamaldehyde reduces voltage-gated calcium channel currents in dorsal root ganglion neurons of rats TRPA1-independently
Serotonin activates a heterogeneous population of cultured rat dorsal root ganglion neurons
Pain-related changes of network oscillations in mice
Munc13–3 is a developmental mediator of tight coupling between release sensor and P/Q-type channels
Dopamine promotes the emergence of rhythmical ripple-like events in prefrontal cortex of mice
Neural correlates of working memory in the mouse prefrontal cortex and ventral tegmental area
Early and localized expression of ion channels and ion channel subunits in the developing mesodiencephalic dopaminergic domain of the mouse embryo
Cortico-striatal microfluidic co-culture for the investigation of the role of acid-sensing ion channels in synaptic transmission
Dynamic-clamp-induced burst discharges in dopamine neurons of the rostromedial substantia nigra in vitro
Full recovery of spontaneous turning bias in an unilateral Intrastriatal 6-OH-dopamine mouse model of Parkinson
N-oleoyldopamine (OLDA) modulates activity of central aminergic neurons through multiple and region-specific mechanisms
Distinct types of voltage-gated calcium channels sensitize inhibitory dopamine D2-autoreceptor responses of Substantia nigra dopaminergic neurons
In vivo recording of identified projection-specific subtypes of midbrain dopamine neurons
Spike train pause detection in midbrain dopamine neurons: identifying the selective effects of KChIP4 knockout
Psychosocial stress promotes food intake via modulation of brain energy content
Hampered brain energy gain upon glucose load in obesity
Lifespan leisure activity profile and its relation to brain metabolism in the elderly
Importance of the microenvironment stiffness for the development of neuronal and Schwann cells in the Peripheral Nervous System
Involvement of OATP1C1 in labeling of oligodendrocytes with SR101
Glycine uptake via Sodium/Neutral Amino Acid Transporters activates a swelling-dependent anion conductance in microglial cells
Panglial gap-junctional coupling mediates calcium signalling between olfactory bulb glial cells
Ca2+-permeable AMPA receptors in periglomerular astrocytes of the mouse olfactory bulb
Significance of Succinate dehydrogenase for glucose metabolism in murine astrocytes
The soluble epoxide hydrolase attenuates pathological vascularization by preventing astrocytes loss in retinopathy of prematurity in mice
Features of CD157 and CD38 expression in neurogenic niches of the brain in experimental Alzheimer's disease
A knock-in mouse model for episodic ataxia carrying a gain-of-function mutation in a glial EAAT anion channel
Optimizing the experimental conditions for neuronal differentiation of human pluripotent embryonal carcinoma (NT2) stem cells
Characterisation of sweat gland derived stem cells for the application in peripheral nerve regeneration
Functional phenotyping of human induced pluripotent stem cell-derived neurons
Evidences for the molecular and cellular heterogeneity of stem-like glioma cells in human glioblastomas and gliosarcomas
R59022: From diacylglycerol-kinase inhibitor to a potent modulator of K+ channels
Regulation of K2P channels by long chain coenzyme A esters - Implications for a novel cardioprotective mechanism
Cell-free expression of two-pore domain potassium channels for use in bilayer experiments
Pharmacological activation of K2P channels
Functional interaction of calcium-activated potassium channels of high conductance and T-type calcium channels transforms phasic into tonic contractility in vascular smooth muscle cells
The Ca2+-activated potassium channel KCa3.1 in the metastatic cascade of A549 non-small cell lung cancer cells
Functional expression of inward rectifier K+ currents in glioma cells
Heteromeric KCNJ10 and KCNJ16 potassium channels: Functional consequences of the rare KCNJ16 variant p.R35Q
Expression and localization of KCNJ16 in various mouse tissues
SPAK and OSR1 Sensitive Kir2.1 K+Channels
Erg1-mediated K+ currents in auditory inner hair cells
Cx43 mediated augmentation of cell motility is associated with enhanced focal adhesion turnover and reduced stress fibres formation
The inhibitory effect of NO on Cx37-dependent intercellular calcium signaling targets the phosphorylation state of tyrosine 332
Functional analysis of the cataract related mutation N188T in human connexin46 (hCx46)
Concatemeric connexins build functional hemichannels and gap junction channels
PKA dependent phosphorylation of the C-terminal part of Connexin 43 reduces cell migration
Quantitative analysis of distribution of dendritic Cav1.2 (L-type) Ca2+ channels relative to mGluR1α in hippocampal interneurons
Corticosteroids and insulin upregulate the cardiac L-type Ca2+ current and increase the expression of the L-type Ca2+ channel α1C-subunit in rat cardiomyocytes
Cav2.3 voltage-gated Ca2+ channels in atrioventricular signal transduction
Expression of transmembrane channel-like gene 6 is significantly higher in skeletal muscles of mdx mice than in wild type animals
Opioid receptor activation causes inhibition of TRPM3 channels in the peripheral nervous system
TRPV4 (transient receptor potential vanilloid 4) ion channel activity is stimulated by an increase in intracellular cAMP
TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophils
Cellular and molecular relevance of classical transient receptor potential 1 in chronic hypoxia-induced pulmonary vascular remodeling
Flavonoid inhibition of TRPM8 and activation of TRPA1
Modulatory role of bile acids on the signaling of purinergic receptors in normal rat cholangiocytes (NRCs)
nvestigation of functional interaction of purinergic P2X4 and P2X7 receptors
Physical interaction of purinergic P2X4 and P2X7 receptors
Role of G338 of the second transmembrane domain in gating of the human P2X7 receptor
Differential effects of phosphocholine on metabotropic and ionotropic nicotinic receptors containing subunit CHRNA9
Prestin: Investigation of the central cavity by a cysteine accessibility study
The role of non-specific cation channels in spontaneous activity and tone of smooth muscle
Evidence for channel-mediated transport of NH4+ across ruminal epithelia of Sahiwal and Holstein-Friesian cattle
Decreased barrier function of tight junctions enhances the gap junction coupling in intestinal epithelial cells
The expression and function of anoctamin 2 in the retinal pigment epithelium
Na+ recirculation drives high-rate volume resorption in an airway epithelium - insights from in-silico modelling
Differential Cl- secretion triggered by luminally applied ATP and acetylcholine in porcine airway epithelium
Chitosan-based delivery of mRNA for cystic fibrosis therapy
Paracellular phosphate permeability in the intestine
Potential role for astrocytic and neuronal monocarboxylate transporters in epilepsy
High glucose increases transport capacities of the human organic cation transporters hOCT1 and hOCT2 and of the human multidrug and toxin extrusion transporter hMATE1 expressed in HEK293 cells
‘Proton antennae’ facilitate lactate flux by monocarboxylate transporters
Gene expression patterns associated with the phenotypic switch of renin cells
Relation of Renin related genes from the literature and from high throughput gene expression experiments
Kidney phenotype of mice with VEGF deficiency in renin-producing cells
Aliskiren and kidney function
Erastin induced ferroptosis in isolated perfused proximal tubules
The role of prostaglandins in renal blood flow autoregulation
High K+ intake induces hypertension independently of MR and ENaC activation in sodium replete mice
The C-terminal fragment of agrin (CAF), a novel marker of renal function, is filtered by the kidney and reabsorbed by the proximal tubule
Kidney phenotype of uninephrectomized mice with induced renin deficiency or renin cell ablation
Effect of ferumoxytol on control of renal hemodynamics and oxygenation in rats
Simultaneous measurements by near-infrared spectroscopy and invasive probes yield complementary informations about control of renal haemodynamics and oxygenation
Dietary intake of phosphate stimulates renal salt absorption and increases blood pressure
Examining renal adaptation to changes in dietary phosphate intake in humans by use of urinary extracellular vesicles (‘exosomes’)
Inhibition of microtubule polymerization affects actin coat formation on the fused secretory vesicles in alveolar type II cells
Mechanobiophysics of the alveolus - Reconstruction of strain and forces at the gas-blood-barrier
Interfacial sensing regulates alveolar barrier function in lung epithelial monolayer
Effects of hydrostatic pressure on epithelial cells: establishing a modified Ussing chamber technique
Establishment of a co-culture to mimic the alveolar-capillary barrier in vitro
Interleukin-13 disturbs barrier function in human lung epithelia
Effects of milk on the porcine intestinal barrier function
Effect of inflammatory factors on air liquid interface epithelia
Comparative analysis of cholera toxin and lipopolysaccharide effects on rat small intestinal epithelial cells by TEM
Impact of casein kinase 2 on transcriptional mineralocorticoid receptor activity
The role of JAK/STAT signaling pathway and TNF-α crosstalk in human colorectal cancer
Proof of principle - an in-vitro model to compare the efficiency of therapeutically applied anti-TNF-α-antibodies
Expression of inflammatory mediators is susceptible to extracellular acidosis in monocyte- and macrophage-like cell lines and primary cells
The protein-tyrosine phosphatase SHP-2 counteracts IL-1β induced endothelial inflammation
15-Deoxy-Δ12,14-prostaglandin J2 reinforces the anti-inflammatory capacity of endothelial cells with a genetically determined nitric oxide deficit
Molecular mechanisms of the cytotoxic action of Erufosine in hypoxic tumor cells
Fumaric acid esters improve blood-brain barrier integrity and neuronal survival during cerebral ischemia-reperfusion injury
High-resolution respirometry on proximal tubules from mice
Does metabolic stress preferentially affect fast spiking interneurons?
Ingenol pre-conditioning protects against inflammation- and hypoxia/reoxygenation-induced loss of endothelial barrier function
Hydrogen peroxide formation by Nox4 limits malignant transformation
The endoplasmic reticulum chaperone calnexin is a NADPH oxidase Nox4 interacting protein
Quantitative redox imaging in complex preparations by dual-laser based excitation ratiometric 2-photon microscopy
Knock out of the NADPH oxidase protein NoxO1 protects from dextrane sodium sulfate (DSS)-induced colitis
Novel redox-targets of NADPH oxidase 4
What NADPH-stimulated chemiluminescence assays indeed detect? Lessons from a Nox1-Nox2-Nox4 triple knockout
Transcriptional regulation of NADPH Oxidase 4 (NOX4) - Implication of JUN- and NFAT like elements
The AMPKα2 regulates neutrophil mitochondrial metabolism, apoptosis and post-ischemic revascularization through modulation of the HIF-1α pathway
Towards the generation of an organotypic human sweat gland model system
PAFAH1B1 is important for endothelial cell angiogenic function
Evaluation of dynamic changes of Connexin43 in endothelial cells using non-canonical amino acid tagging
Phosphatidylinositol-(4,5)-bisphosphate sensors target functionally distinct plasma membrane microdomains
Effect of changes in cell volume and cell plasma membrane area on membrane protein density determination
Mitochondria of pancreatic beta cells exhibit different behaviour to glucose dependent on their local distribution
Influence of the adiponectin paralogs CTRP9 and CTRP13 on the insulin signaling pathway in adult rat cardiomyocytes
Quercetin stimulates insulin secretion and reduces viability of INS-1 rat insulinoma cells
Nocodazole Induced suicidal death of human erythrocytes
Effects of retinoid-X receptor-(RXR-) and retinoic acid receptor (RAR) isoform-selective synthetic retinoids on cultures of stem-like glioma cells
Cisplatin (CDDP) induces modification of the intracellular calcium signaling in SH-SY5Y neuroblastoma cells: the role of calcium regulating proteins
Combinatory treatment with anticancer drugs (cisplatin (CDDP), topotecan (TOPO)) and pharmacological modulators of calcium signaling enhances cytotoxic effects in human neuroblastoma cells
The LncRNA HIF1α-AS1 mediates the response to acriflavine in human endothelial cells
Evaluation of Animacroxam, a newly developed dual-mode compound for the treatment of testicular germ cell cancer
Expression of Rho kinase and myosin-light chain kinase in the aging human detrusor
Endothelial atrial natriuretic peptide signalling attenuates chronic hypoxia-induced pulmonary hypertension and inflammation
Cigarette smoke extract abrogates atheroprotective effects of high laminar flow on endothelial function
Production of ACE-inhibiting dipeptide isoleucine-tryptophan and its role in prevention of hypertension
Improved vascular function after mineralocorticoid receptor antagonist therapy in patients with coronary artery disease
Bioavailability of the ACE-inhibiting peptide Isoleucine-Tryptophan after oral intake of whey hydrolysate in man
KATP channels contribute to VSMC membrane potential in distal renal interlobar arteries
Influence of gap junctional communication on microvascular network of the chicken chorioallantoic membrane
Frequency-dependent synaptic fatigue causes instability of neurogenic tone in rat inferior vena cava
Importance of transmembranal calcium influx and calcium release from SR during isobaric (meiotonic) contractions in smooth muscle
Impact of the adiponectin paralog CTRP13 on endothelial cells
Key role of NADPH oxidase 4 in a model of reversible endothelial dysfunction
Inhibition of eNOS phosphorylation on tyrosine656 in mice protects against endothelial dysfunction
Effects of mineralocorticoid receptor blockade by spironolactone on vascular calcification
VASP, but not EVL, is required for the conduction of endothelium-dependent dilations in vivo
Reduced maximal contraction and contraction velocity in hearts of mice lacking a mechanism for isoproterenol-induced proteasome regulation
Interleukin-6 mediates titin phosphorylation and could be involved in the rapid increase in cardiomyocyte stiffness in the acute phase after myocardial ischemia/reperfusion
Gender- and age-based differences of cardiovascular remodelling in spontaneously hypertensive rats (SHR)
Alterations in gene expression levels due to heart failure in cardiac p38 MAPKinase KO mice
The insulin-like growth factor 1 receptor in cardiomyocytes is dispensable for the beneficial effect of insulin-like growth factor 1 on the left ventricular function after myocardial infarction
Pressure-independent cardiac protective actions of C-type natriuretic peptide in experimental hypertensive heart disease
Anti-fibrotic and anti-inflammatory effects of C-type natriuretic peptide in a genetic model of hypertension
Lysyl oxidase in cardiac fibrosis
Regulation of cardiac autophagy by SPRED2
miR-221/222 in heart hypertrophy
MicroRNA 208b in epidermal growth factor receptor-mediated changes in the heart
Echocardiographic analysis of ejection fraction after myocardial infarction in mice - Validation of single-plane parasternal long axis view measurements and the bi-plane Simpson method
NMDA receptor-dependent depotentiation is enhanced after status epilepticus
Characterisation of perampanel action in glioma-associated epilepsy
Effect of sodium bromide on CA1-pyramidal cells, GABAergic transmission, synaptic plasticity and pilocarpine-induced seizures
Traumatic brain injury induces changes in synaptic longterm plasticity connected to alterations in protein degradation systems
The proinflammatory cytokines TNFα and IL-1ß diminish amplitudes of cortical spreading depression (CSD) via activation of GABA release - is this a common way of neuroprotection?
Validation of a recombinant human stem cell line for the identification of ligand gated chloride channel blockers within the scope of in vitro neuro-physiological, -pharmacological and toxicological screening
Spontaneous bicuculline-mediated epileptic events in rat hippocampal slices: Neuronal populations and their field potentials
Oxidative stress during in vitro maturation of fast spiking basket cells alters hippocampal gamma oscillations - a novel model of schizophrenia
Changes in synaptic plasticity and gene expression in the brain of a new transgenic mouse model of systemic hyperammonemia
Voltage sensitive phosphatases as tools to generate molecular switches with defined substrate specificities
Optogenetic stimulation of cyclic GMP in Drosophila motoneurons
Functional and genetic dissection of mechanosensory organs of Drosophila
Respiration in freely moving mice: Comparing plethysmography, nasal thermal probe and olfactory bulb local field potentials
The contribution of the two binding sites to the opening of the adult nicotinic acetylcholine receptor
Structural dynamics of Adhesion class G protein-coupled receptors
Electrophysiological characterization of bile salt effects on ionotropic glutamate receptor function
Differential regulation of TRPM3 splice variants by intracellular signaling pathways
Adenosine receptor A1 modulates the potassium conductance of olfactory bulb mitral cells
A1 receptor-mediated modulation of recurrent inhibition in mouse olfactory bulb mitral cells
Electrical coupling in A17 cells modulates calcium signaling and GABAergic inhibition in the rod circuitry
Tonic inhibition in the basal amygdala is under control of modulatory transmitter systems
Properties of subthreshold membrane potential oscillations of somatostatin-expressing GABAergic interneurons of the mouse cingulate cortex in vitro
Modulation of fear-relevant circuits of the amygdala by opioids
The translational regulator Orb2 has prion-like properties and mediates synaptic plasticity
Role of cAMP-signaling in regulation of activity-dependent BDNF secretion in hippocampal neurons
Behavioural state drives structural plasticity of parvalbumin-positive interneurons in the dentate gyrus
Activation of the prefrontal-thalamic-hippocampal network in a touch screen based working memory task
Investigations on the function of transcranial oscillatory stimulation
Consequences of altered dendritic arborization in hippocampal networks - linking molecular signaling, neuronal morphology and cognitive performance
Lactate is a sufficient energy substrate for sharp-wave ripple complexes in vitro, but does not sustain gamma oscillations
Differential effects of oxytocin on oscillations in acute mouse hippocampal slices
CA1 laminar distribution of theta-gamma cross-frequency coupling patterns in mice
Non-random synaptic topology in local microcircuits of excitatory and inhibitory neurons in the presubiculum
Fast effects of neurosteroids on memory-related hippocampal network oscillations
How spike pattern can determine signaling and expression of STDP
Plasticity of individual hippocampal mossy fiber synapses involves intracellular calcium stores
Intrinsic and dopaminergic modulation of hippocampal mossy fiber bouton resting membrane potential
The ε-subunit of the epithelial sodium channel (Xenopus laevis) alters channel open probability
Comparative characterization of the ε- and α-subunit of the epithelial sodium channel in Xenopus laevis
Characterization of acid sensing ion channels in glioblastoma cells
Volatile anaesthetics modulate Acid-sensing Ion channels (ASICs)
Towards elucidating the contribution of each cAMP-binding site to HCN channel gating
The effect of newly designed cAMP analogues on HCN2 Channels
Functional impact of subunit types and subunit positions in heterotetrameric olfactory CNG channels
Activation of CNG channels by novel cAMP and cGMP derivatives
A fast microfluidic based 30-barrel application system to functionally characterize ligand-gated ion channels
Differential regulation of Na+ current density in bipolar and pyramid-shaped neurons by exposure to inflammatory cytokines derived from activated microglia
Sodium channel subunit β4 influences the binding of ProTx-II to Nav1.7 and Nav1.2
Use-dependent inhibition of the cardiac sodium channel Nav1.5 by the opioid oxycodone
Pyrethroid insecticide induces resurgent-like currents in human sodium channel Nav1.5
The endothelin-A receptor is expressed by renin cells of the kidney but is of less relevance for the physiological control of renin synthesis and secretion in vivo
Analysis of vasopressin V1a and V2 receptors distribution in the mammalian kidney
The effect of leptin and resveratrol on Jak/Stat pathways and Sirt-1 gene expression in the renal tissue of ischemia/reperfusion induced rats
Phenotyping of Fam20a-knock out-mice
Opposing effects of lithium on the activity of the transcriptional regulator NFAT5 in collecting duct cells
Hydrochlorothiazide does not acutely acidify urine
The H+/sucrose symporter SLC45A3, a candidate for an osmolyte transporter in the kidney
Dietary adaptation to high and low phosphate in the absence of the intestinal sodium phosphate symporter NaPi-IIb
Hepatic and renal handling of dantrolene and 5-hydroxy dantrolene (5-OH dantrolene) by organic anion transporting polypeptides (OATPs) and organic anion transporters (OATs)
Electrophysiological properties and effects of excess dietary calcium intake along the cortico-medullary axis of the thick ascending limb of the loop of Henle
Sites and principles of ammonia excretion in marine mussels
Altered activity of the epithelial sodium channel (ENaC) in the aldosterone-sensitive distal nephron (ASN) of mice with AT1a receptor deficiency
Function of an alternative transcript of the WNT1-inducible signaling pathway protein 1 gene in human renal cells
Depletion of ATP6AP2 in AS4.1 cells regulates the expression of ciliogenesis and cell-cycle genes thereby arresting cell cycle in G0/1 phase
The Na+/H+ exchanger 1 modulates pH-dependent cell-cell contacts in human melanoma
Does NHE1-mediated invasion of human melanoma cells depend on their cortical stiffness?
Angiotensin II and Losartan change NHE1-dependent behavior of melanoma cells
Influence of hormone-like fibroblast growth factors on viability of pancreatic beta cells and insulin release
Beyond blood pressure: Cardiac atrial natriuretic peptide regulates pancreatic β-cell proliferation in experimental diabetes
Flavonoid supplements deplete systemic glucose uptake in humans
Association of circulating irisin with oxidative stress and insulin resistance in premenopausal lean and obese women
Influence of extracellular acidosis on matrix proteins
Role of the electrogenic sodium bicarbonate cotransporter NBCe1 and carbonic anhydrase II for proton dynamics in cortical astrocytes
Cytosolic sodium dynamics in mouse cortical astrocytes
Localization and regulation of intestinal acid-base transporters during metabolic acidosis
Novel zinc phthalocyanine as a promising photosensitizer for photodynamic therapy of esophageal cancer
Isolation of highly malignant lung cancer cells by platelet affinity selection
Sperm nuclear DNA fragmentation and fertility status
Expression of the Wilms tumor protein WT1 in neuroblastoma cells is stimulated in hypoxia
Impact of hypoxia-induced carbonic anhydrase IX on H+-coupled lactate transport in MDA-MB-231 human breast cancer cells
The significance of hypoxia inducible factor (HIF) - 1α on the course of an acute infection with murine cytomegalovirus
Effects of hypoxia on the transport of glucose across the equine jejunum epithelium
The Influence of hypoxia inducible factor 2 on the development of neural stem cells
The relevance of expression of myoglobin in breast cancer for adaptation on hypoxia
Destruction of a distal hypoxia response element abolishes trans -activation of the PAG1 gene mediated by HIF-independent chromatin looping
ArhGAP29 fine tunes RhoA activity and its downstream signaling in hypoxia
FIH regulates cellular metabolism through hydroxylation of the deubiquitinase OTUB1
Impact of cellular availability of the transcription factor ARNT and import proteins Importin-α on radiation sensitivity in different cell lines
Phosphorylation of importin α1 as an effector of the binding of importin α1 to cargo proteins with nuclear localisation signals and importin β
Effects of an altered subcellular localisation of the transcription factor ARNT on HIF signalling
CO2 permeability of rat ventricular cardiomyocytes
Maximal oxygen consumption of mice deficient in CO2 channels
Sphingolipid signals regulate hypoxia-inducible factors in macrophages and fibroblasts
Electromyographical study of trunk muscles in upright and bent postures
Functional capacity of trunk extensors is almost identical between sexes
Glucose uptake during intermittent high-intense exercise of a small muscle group
Effects of exercise training on hepatic oxidative stress and antioxidant status in aged rats
A practical class to teach the physiology of mechanical ventilation using a lung simulator
Cardiopulmonary reaction to hypoxia in rats and the influence of adrenergic blockade
Does preselection of medical students with respect to skills in natural sciences outperform overall performance presented at the university entrance qualification?
Interorgan communication between heart and skeletal muscle
Distribution of myosin heavy chain isoforms in the skeletal muscle of humans. Implications for sports and medicine
Profound changes in the gene expression of skeletal muscle lacking the type 1 ryanodine receptor (RYR1)
Fibroblasts from diaphragms of dystrophin-deficient mdx mice show higher expression of endothelin-1 receptor type B than those from wildtype mice
The actin cytoskeleton in embryonic fibroblasts from caldesmon deficient mice
The influence of mitochondrial DNA on sarcomere shortening of isolated cardiomyocytes
Exercise-induced cell free DNA in human plasma is predominantly released from cells of the haematopoietic lineage
Pressure activates endothelial myosin
The histone demethylase PHF8 maintains angiogenesis by regulating mRNA splicing
The role of AMP-activated protein kinase in angiogenesis
Atrial natriuretic peptide attenuates hypoxia-induced release of VEGF from astrocytes and thereby pathological retinal neovascularization
The polarity protein Scrib controls endothelial adhesion and lateral junctions formation
Supramolecular-structure of VE-cadherin-based endothelial adherens junctions
Sodium determines EnNaC expression and endothelial nanomechanics in aldosterone synthase (Cyp11b2) knockout mice
Low dose, long-term clarithromycin therapy ameliorates inflammatory mediators-induced loss of endothelial barrier function
The omega-3 diol 19,20-dihydroxydocosapentaenoic acid regulates vascular permeability in diabetic retinopathy
Endothelium activates latent MMP2 and MT1MMP in human aortic smooth muscle cells
Influence of biophysical properties of filter supports on transendothelial resistance determined by impedance spectroscopy of endothelial monolayers
Carbon dioxide as a protective compound for the ruminal epithelium
Assay development for electrophysiological studies in the hermatypic coral Stylophora pistillata
Role of soluble adenylyl cyclase on barrier function of human umbilical vein endothelial monolayers
Human embryonic stem-cell derived cardiomyocytes: Maturation on stiff matrix induces pure β-myosin protein expression and adult-like functional properties at the single-cell level
Properties of αMHC-promoter selected and Nkx2.5 programmed ES cell derived cardiomyocytes
Reduced excitability and intercellular coupling lead to slow conduction in cultures of stem cell-derived cardiomyocytes
Optogenetic stimulation permits long-term assessment of contractility in organotypic tissue cultures of murine myocardium
Automated Cardiac Action Potential Analysis (CAPA)
Spot on Cardiac Arrhythmia: Spatiotemporal pattern generation in optogenetic cardiac systems
The disease-associated HCN4 channel variant V759I is not sufficient to explain dysfunction of the sinuatrial node
Impairment of ventricular repolarization and induction of arrhythmias by mechanical unloading in a rodent model of heterotopic heart transplantation
Heart and smooth muscle experiments in virtual laboratories: SimHeart and SimVessel
Titin properties in the ageing heart
The skeletal muscle contraction mode regulates cardiac muscle phenotype and functional parameters in rats
TGFβ induces attenuation of cell shortening via activation of ALK5 and PI3K in adult cardiomyocytes of rat