OC-74 The metabolic consequences of feeding types of preterm neonates

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Background and aimHigh risk newborns are often much smaller than healthy infants when are discharged from hospital. Different types of feeding: breastmilk, formula or mixed can influence growth rates and improve development.The aims of the study were to evaluate the growth rates; catch–up rate and some biological parameters of the nutritional status such as: hemoglobine, iron, calcium, phosphor, magnesium, the level of plasmatic protein, nitrogen balance at differents ages : 1-2-4-6 months in three different types of nutrition – breastmilk, special formula for premature, breastmilk with premature formula or started formula.Material and methodsA retrospective study was performed in a tertiary neonatal care unit between 2011–2013 in the County Hospital of Cluj, Romania on 383 infants presented to periodical examination in the follow-up program: 465 records. We divided into 3 categories : group I-VG≤32 weeks, group II-VG between 32–36 weeks and group III-VG≥36 weeks of gestation. The evaluation consultations were performed at 1-2-3-4-5-6 months.Each evaluation consisted of determining: weight, CBC, calcium, iron, magnesium, protein, Blood Urea Nitrogen (BUN) levels.Informed consent was obtainedStatistical analysis was made with Microsoft Excel 2016 and IBM SPSS v.23.ResultsGrowth rate up to 6 months wasn ‘t significantly influenced by the type of feeding (p=0.319).Hemoglobine at 2 months highlighted statistically higher values in formula fed group: 11.77±2.07g compare with premature formula fed group:10.848±1,7556g(p=0.008).The values of iron at 2 months hasn’t presented any significant differences according to the types of feeding (p=0.475). There is a significant decrease of iron levels that occurs gradually with age in the breastfed ones, r=−0.89.Different calcium levels were registered according to types of feeding (p=0.003) until 6 months.Magnesemia were not influenced by feeding type at any groups.BUN in group I was significantly smaller in breastfed compared with premature formula fed infants(p=0.000) at 2 months. Up to 6 months the value is significantly lowered in cases of breastfed, p=0.001.The values of the protein in≤32 weeks is directly influenced by the type of feeding p=0.024.Protein levels is significantly influenced in group II(p=0.026).Phosphatemia is significantly influenced by the type of feeding in group II(p=0.043).ConclutionSIncrease in bodyweight of newborns under 32 SS isn’t influenced significantly by the type of feeding up to 6 months.Calcium registered significantly different values under the different types of feeding in the prematures≤32 weeks of gestation in the first 6 months of life.Phosphoremia is significantly influenced by the type of feeding in the second group.Iron drops significantly with age in breastfedgroup.The level of protein in group I is directly influenced by the type of feeding.At 2 months of age BUN is significantly influenced by the type of feeding in the first group.

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