P195 Growth hormone and insulin-like growth factor ii in mothers and their newborn children with intrauterine growth retardation

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Abstract

Objective

to evaluate the level of GH and IGF II in mothers and their newborn children with different variants of intrauterine growth.

Materials and methods

175 pairs of mother – newborn child were studied. In the 1 st group there were 46 children ‘Light for gestation age’ (P05.0 according to the ICD-10), the 2-nd ‘Small for gestation age’ (P05.1), control – 45 children without trophic disorders.

Results

Infants of the 1 st group had a level of GH 21,28 ng/ml, compared with the 2-nd which was 27.3% lower. Newborns of the 1 st group had the lowest level of IGF II – 136,56 mg/ml, in the 2-nd it was 179,65, and 191,82 in control. GH level of mothers in the 2-nd group was 0.91 ng/ml, which was less than in the 1 st group by 28.9%, and less than control by 30.5%. In each group compared rates of hormones depending on the degree of IUGR. In infants with birth weight less than P3 concentration of GH in their mothers was 1.19 ng/ml, the level of IGF II was 360,13 mg/ml. In infants P3-10, the level of GH of their mothers was higher by 10,5% (to 1.33 ng/ml), and IGF II – 27,2% (494,5 mg/ml) than in group with birth weight less than P3.

Results

Thus GH and IGH II have important role in development of IUGR

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