P309 Is the incidence of postinfectious glomerulonephritis increasing?: 13 cases with postinfectious glomerulonephritis from a single centre in november-december 2016

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Abstract

The incidence of acute postinfectious glomerulonephritis (PIGN) has decreased worldwide, particularly in developed countries. Although PIGN continues to be the most common cause of acute nephritis in children globally, it primarily occurs in developing countries.

There is a certain increase in the number of patients with postinfectious glomerulonephritis (PIGN) in Department of Paediatric Nephrology at Cukurova University during November-December 2016. Clinical, laboratory and follow up results of the 13 patients that have PIGN are studied. Paediatricians‘ diagnostic approaches and the reasons for referral were evaluated in patients with clinical symptoms of PIGN. The patients are diagnosed PIGN in the presence of haematuria, proteinuria, evidence of recent streptococcal infection (increase of ASO and throat swab positivity for pharyngitis), low serum C3 levels with normalisation on 8 weeks follow up. 13 patients (5 male, 8 female) are conducted into the study. Mean age was 9 (3-15). All of patients have had recent infection. The symptoms of patients at the time of admission were oedema (70%), macroscopic haematuria (23%), hypertension (15.3%) and respiratory distress (15.3%). 7 of the patients (53%) had blood pressure higher than 95.percetile for age, gender and height. Non nephrotic proteinuria was detected in 11 patients. All patients had low C3 levels. Two of the patients had cardiac systolic dysfunction, pulmonary oedema, and a referral to our hospital. There was improvement in clinical findings with fluid restriction and diuretic therapy in patients‘ follow-ups. Because of nephrotic proteinuria and acute kidney injury, kidney biopsy was done to one of the patients and diagnosed with diffuse proliferative glomerulonephritis.

PIGN is observed with higher incidence in the developing countries. In these patients with different clinical presentation, it was aimed to draw attention of paediatricians.

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