Apocrine Differentiation in Breast Epithelium

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SummaryThe definition of the apocrine cell al the light and electron microscopic as well as immunohistochemical and genetic levels is presented. Apocrine cells are believed to be normal constituents of the breast epithelium and are also present in most benign and many malignant conditions, such as cystic disease, apocrine hyperplasia, apocrine adenoma, fibroadenoma with apocrine differentiation, sclerosing adenosis with apocrine differentiation, apocrine adenosis, ductal adenoma, papilloma and papillary carcinoma, lobular carcinoma in situ, ductal carcinoma in situ, invasive carcinoma (including apocrine carcinoma), pleomorphic invasive lobular carcinoma, and histiocytoid invasive carcinoma.

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