Spitz Nevus and its Histologic Simulators

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Summary:Spitz nevi continue to pose a considerable diagnostic challenge to the histopathologist. Key features of Spitz nevus and its variants are discussed and contrasted with the telltale signs of malignancy of “Spitzoid” melanomas. The importance of the histologic features of the deep, rather than superficial, part of the lesions is emphasized.

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