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Cryolipolysis is a noninvasive technique for reducing localized subcutaneous fat that is based on adipocyte's high sensitivity to cold. We report a case of a lateral thigh skin necrosis postcryolipolysis, performed by a dermatologist, on a 42-year-old woman without any significant medical history. The treatment of these lesions required a surgical procedure (necrosectomy associated to direct suture), performed in the operating room. Complete wound healing was obtained in 2 weeks, with a satisfying aesthetic result at 6 months.