Optimal body weight for health and longevity: bridging basic, clinical, and population research
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific
Reductions in serum IGF-1 during aging impair health span
Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1
A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging
Aging is associated with increased regulatory T-cell function
P44, the ‘longevity-assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion
Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Smurf2 regulates hematopoietic stem cell self-renewal and aging
Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis
The contribution of visceral fat to improved insulin signaling in Ames dwarf mice
Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration
Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging
Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N -acetyl-cysteine
Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts
Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness