Evaluation of factors that may be responsible for cyclic change of CA125 levels during menstrual cycle

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To evaluate the factors responsible for fluctuation of CA125 levels during menstrual cycle


The study was performed with patients who had undergone hysterectomy for benign gynecological disease (group I, n = 30) and patients who had undergone laparoscopy for tubal ligation (group II, n = 30) or for investigation of pelvic cause of infertility (group III, n = 24) and showed normal laparoscopic findings. In groups II and III, blood samplings for serum CA125 determination were performed in menstrual and no-menstrual period. In group I, sampling times were determined by using estrogen and progesterone levels. Mean serum CA125 concentrations were compared using one-way analysis of variance (ANOVA) for multiple group comparisons and paired t test for within-group comparisons.


Intra-individual serum CA125 concentrations of group I was not significantly different (P > 0.05). In group II, mean menstrual CA125 concentration was on average 18.2% higher than that of non-menstrual concentration (P < 0.001). Group III showed a similar pattern to that of group II, with a difference of 22% (P < 0.001). Mean CA125 concentration of group I in both menstrual and non-menstrual period was lower than those of groups II and III (P < 0.001). However, there was no significant difference between groups II and III when compared with the corresponding menstrual and non-menstrual CA125 concentrations (P > 0.05).


Endometrium is responsible for the cyclic changes in serum CA125 concentration during menstrual cycle

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