Three-Dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing

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Abstract

Rapid and automatic development of three-dimensional (3D) human micro-tissue chips which integrate

over 400 micro-arrays of simplified multilayered structures is carried out using inkjet printing technology. Comprehensive high-throughput assays of liver functions using the simplified 3D liver structures revealed highest functions of a sandwich structure of endothelial cells and hepatocytes. These 3D-human tissue chips may enable “total-human tissue models” for tailor-made drug screening.

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