Large-Scale Fabrication of Free-Standing, Micropatterned Silica Nanotubes Via a Hybrid Hydrogel-Templated Route

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Free-standing, micropatterned silica nanotube membranes are in situ fabricated using a micropatterned silica-coated collagen hybrid hydrogel as template. They are substrate-free, and not only maintained their micropatterned microstructure well, but also exhibited strong cell contact guidance ability to direct cell alignment and differentiation, indicating their good potential for biomedical applications.

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