New Insights Into Alzheimer's Disease Amyloid Inhibition: Nanosized Metallo-Supramolecular Complexes Suppress Aβ-Induced Biosynthesis of Heme and Iron Uptake in PC12 Cells

    loading  Checking for direct PDF access through Ovid

Abstract

Nanosized metallo-supramolecular compounds

[Ni2L3]4+ and [Fe2L3]4+, can not only strongly inhibit Aβ aggregation but also reduce the peroxidase activity of Aβ–heme. Further studies demonstrate that through blocking the heme-binding site, these two compounds can suppress Aβ-induced biosynthesis of heme and iron uptake in PC12 cells. This work provides new insights into molecular mechanisms of Aβ inhibitors on Aβ-mediated neurotoxicity.

Related Topics

    loading  Loading Related Articles