New Insights Into Alzheimer's Disease Amyloid Inhibition: Nanosized Metallo-Supramolecular Complexes Suppress Aβ-Induced Biosynthesis of Heme and Iron Uptake in PC12 Cells

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Nanosized metallo-supramolecular compounds

[Ni2L3]4+ and [Fe2L3]4+, can not only strongly inhibit Aβ aggregation but also reduce the peroxidase activity of Aβ–heme. Further studies demonstrate that through blocking the heme-binding site, these two compounds can suppress Aβ-induced biosynthesis of heme and iron uptake in PC12 cells. This work provides new insights into molecular mechanisms of Aβ inhibitors on Aβ-mediated neurotoxicity.

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