Facile Fabrication of Polyanhydride/Anesthetic Nanoparticles with Tunable Release Kinetics

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This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles.

Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0–100% drug loadings are fabricated. Drug release kinetics are dictated by nanoparticle composition allowing future tuning for therapeutic applications.

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