High Aspect Ratio Elongated Microparticles for Enhanced Topical Drug Delivery in Human Volunteers

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Abstract

Delivery of therapeutics into skin is hindered by the epidermal barriers.

To overcome these barriers for the treatment of skin diseases, a cutaneous delivery method capable of field treatment using silica-elongated microparticles is developed. The microparticles are massaged into the skin using a 3D-printed microtextured applicator resulting in significant field-directed drug delivery enhancement.

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