Annals of Human Genetics. 68(4):376–380, JULY 2004
PMID: 15225163
Issn Print: 0003-4800
Publication Date: July 2004
A Note on the Genome Scan Meta-Analysis Statistic
J. Koziol;A. Feng;
+ Author Information
Biomathematics Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037
Abstract
Wise and colleagues (Ann. Hum. Genet. (1999) 63: 263-72) introduced a rank-based statistical technique for meta-analysis of genome scans, the Genome Scan Meta-Analysis (GSMA) method. We provide an alternative derivation of the null distribution of the GSMA statistic, with extensions, and we suggest approximations to the distribution of the GSMA statistic that may be useful in applications.