HIV-1 natural viral suppressors: control of viral replication in the absence of therapy

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Abstract

The objective of this study was to identify and define a cohort of HIV-1-infected individuals with the ability to suppress HIV-1 replication naturally (patients with undetectable viral loads for at least 2 years without antiretroviral drugs). Proviral DNA ranged from one to 74 copies/106 peripheral blood mononuclear cells, with the mean value lower by 1–2 logs than long-term non-progressors. This ability to control HIV-1 viral replication naturally has led us to refer to them as natural viral suppressors.

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