Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers

    loading  Checking for direct PDF access through Ovid

Abstract

Broadly reactive neutralizing activity (brNA) against HIV-1 is observed in 10–30% of infected individuals and generally takes 2–4 years to develop. Here, we show that two elite neutralizers, infected through injecting drug use, developed brNA around the first year postseroconversion (post-SC), whereas criteria for elite brNA were fulfilled around 30 months post-SC. These results indicate that brNA does not necessarily require multiple years to develop and they should encourage the search for vaccines that can elicit protective humoral immunity.

Related Topics

    loading  Loading Related Articles