Abacavir use and risk of recurrent myocardial infarction

    loading  Checking for direct PDF access through Ovid



To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI.


International multicohort collaboration with follow-up from 1999 to 2016.


The rate of recurrent MI was described among D:A:D participants who experienced an index MI whilst in the study, and who remained under follow-up beyond 28 days after this MI. Follow-up was considered to the date of next MI, death, 1 February 2016 or 6 months after last clinic visit. Poisson regression models considered associations between recurrent MI and exposure to ABC (use at index MI, current post-MI exposure and cumulative exposure), before and after adjusting for calendar year.


The 984 individuals who experienced an index MI during the study (91.3% male, median age 51 at index MI) were followed for 5312 person-years, over which time there were 136 recurrent MIs (rate 2.56/100 person-years, 95% confidence interval 2.13–2.99). Rates were 2.40 (1.71–3.09) and 2.65 (2.10–3.21)/100 person-years in those who were and were not on ABC, respectively, at the index MI, and 2.90 (2.01–3.78) and 2.44 (1.95–2.93)/100 person-years in those who were and were not currently receiving ABC, respectively, post-MI. No association was seen with recurrent MI and either cumulative exposure to ABC [relative rate 0.86 (0.68–1.10)/5 years], receipt of ABC at index MI [0.90 (0.63–1.29)] nor recent post-MI exposure to ABC [1.19 (0.82–1.71)].


Among people with a previous MI, there was no evidence for an association between use of ABC post-MI and an elevated risk of a recurrent MI.

Related Topics

    loading  Loading Related Articles