Soluble interleukin-2 receptor decrease in the sera of HIV-infected patients treated with zidovudine


    loading  Checking for direct PDF access through Ovid

Abstract

Laboratory parameters which are modified following administration of zidovudine are becoming increasingly useful in monitoring the efficacy of treatment of early stages of HIV-1 infection. The serum levels of soluble interleukin (slLR)-2 receptor, which have been reported to increase early in HIV-1 infection, were found to be significantly lower in 24 patients being treated with zidovudine than in 69 patients who were not treated, 28 of whom had CD4+ counts >400 × 106/I, and 41 ≤400 × 106/I, respectively (P < 0.0001). A prospective study group of 33 subjects treated with zidovudine demonstrated a decrease in slL-2R during therapy (base values 2113 ± 1131 versus 1444 ± 728 after 90 days of therapy; P < 0.0007). The reduction of slL-2R was greater in those subjects were p24 antigen became negative during treatment. slL-2R therefore seems to be a useful tool in the monitoring of therapy with zidovudine.

    loading  Loading Related Articles