Cell-mediated immune responses to autologous virus in HIV-1-seropositive individuals after treatment with an HIV-1 immunogen


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Abstract

ObjectiveWe hypothesized that cell mediated immune responses to an HIV-1 immunogen (whole-killed, gp120-depleted HIV-1 in IFA, Remune) would include those to autologous virus.MethodsFive chronically HIV-1 infected individuals were examined for HIV-specific immune responses to their own virus (autologous viral antigen) after treatment with an HIV-1 immunogen.ResultsSubjects had low proliferative responses to HIV and p24 antigens prior to immunization and mounted strong lymphocyte proliferative responses to the immunizing HIV-1 virus, native p24, and autologous viral antigen post immunization. Similarly, subjects produced low amounts of interferon-γ in response to HIV and p24 antigens prior to immunization and increased their interferon-γ production in response to HIV-1, native p24, and to autologous antigen post-immunization. Furthermore, β-chemokine responses measured as migratory inhibitory protein-1β production were low at baseline in response to HIV-1 and native p24 antigens and were enhanced post immunization to HIV-1, native p24, and autologous antigen.ConclusionsIn this study HIV-specific immune responses to autologous virus were observed after treatment with an HIV-specific immunogen.

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