Tolerance of efavirenz in children

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ObjectiveTo extend the limited knowledge of efavirenz tolerance in children.MethodAn observational study of 33 children given efavirenz combined with various others agents and followed in a single institution.ResultsFifteen (42%) of the children presented at least one clinically discernable side effect, cutaneous (n = 5), nervous system (n = 10), or both (n = 2). Intolerance led to treatment interruption in seven children but the main symptom was transitory dizziness or other signs similar to those observed in adults.ConclusionEarly, often transient nervous system side effects require careful preparation with the child and his family to avoid premature and inadequate withdrawal from treatment.

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