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FOREWORD
Welcome From the Conference Chairman
Organizing Committee Members
Conference Sponsors and Funding Support
Summary of Tracks
Agenda At-a-Glance
Full Conference Agenda
The global need for microbicides
The role of the Office of AIDS Research, NIH, USA
Microbicides: The Global Opportunities
Expanding our prevention options: the role of the international community in providing an enabling environment for microbicides
The role of the women's health movement in microbicide development
The pathogenesis of sexual mucosal transmission and early stages of infection: obstacles and a narrow window of opportunity for prevention
Up-date on microbicide clinical trials for the Microbicide 2000 Conference
The global drug gap: policy implications for microbicides
Estrogen protects against vaginal transmission of simian immunodeficiency virus
Comparison of microbicides for efficacy in protecting mice from vaginal challenge with herpes simplex 2 virus.
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
Protection of cynomolgus macaque against the cervicovaginal transmission of SIVMAC251 by the spermicide benzalkonium chloride
hu-SCID: A model for the evaluation of vaginal microbicides
An anti-HSV antibody produced in transgenic rice plants prevents vaginal HSV-2 infection in mice
Human vaginal xenografts: a model system for microbicide testing
Inhibition of vaginal infection with simian immunodeficiency virus in progesterone-treated rhesus monkeys by pretreatment with nonoxynol-9-containing spermicidal gel
Issues in the design of randomised controlled trials of vaginal microbicides
A phase III microbicide trial: methodological and ethical issues
PCR-Based quantification of replication-competent HIV-1 in female genital secretions
Methodological issues in microbicide research and development
Approaches to marketing microbicides
Assessment of the potential market-a summary of survey results from 11 European and developing countries
Methods for forecasting from intentions data
What do women want?
Product satisfaction is not associated with choice
Industrial interest in microbicides: trends over the last four years
From product idea to public health impact: lessons learned from the female condom and their applications to microbicides
Biology of mucosal transmission of HIV in the genital tract
Genital tract infection and inflammation: implications for microbicide research
Evaluation of cervicovaginal inflammation and its relevance to HIV-1 transmission
Compartmentalization of HIV-1 within the female genital tract: implications for assessing antiretroviral interventions.
Hydrogen peroxide-producing lactobacilli in women with and without vaginal discharge: evidence for a role in vaginitis prevalence
Infiltration of white blood cells (WBC) into the vagina following vaginal application of Commercial Nonoxynol-9 Preparations
Primary cervical and prostate epithelial cells are not productively infected with HIV-1, but may sequester the virus: implications for sexual transmission
How do microbicide formulation properties govern spreading and retention on vaginal surfaces? mechanistic biophysical analysis
Men's Attitudes towards a potential vaginal microbicide in Mexico, Zimbabwe and the USA
Acceptability of novel, microbicide BufferGel during a Phase I safety trial in Thailand, India, Zimbabwe, and Malawi
Acceptability of topical microbicides among adolescents: implications of psychological development
Ambiguity, sexual pleasure, and the acceptability of microbicidal products in southwest Uganda
Measuring the Acceptability of Microbicides: Problems and Principles
Frequent use of lubricants for anal sex among men who have sex with men: The HIV-prevention potential of a microbicidal gel
Do women want microbicides?: thoughts of African women
Grass-roots mobilization around microbicides: examples from two US-based projects
Chemokine Receptors and HIV entry
The development of novel vaginal microbicides: from the bench to the clinic.
In vitro strategies for the preclinical development of topical microbicides: classes of potential inhibitors
Preclinical properties of the thiocarboxanilide UC-781 as a potential virucidal compound against HIV
HIV infection of human cervical tissue in vitro and the effects of vaginal virucides
Development of novel approaches to the evaluation of virucidal agents: separation of treated virions from test compounds
Pre-clinical characterization of CTC-96 in a non-spermicidal topical virucide
Ex vivo HIV-1 infection of human immature langerhans cells within epithelial tissue explants: a novel model for sexual transmission of HIV-1
Current status of the microbicide pipeline
Treatment of bacterial vaginosis with an acidic buffering gel (BufferGel): pilot study
Antibodies may provide prolonged microbicidal activity due to their long residence time in the vagina
Safety results of a multi-site international Phase I trial of the topical microbicide BufferGel
Dextrin sulfate vaginal gel: interim data from a phase II study in sexually active healthy women at low risk of HIV infection and their male partners
The impact of microbicides on HIV and STD transmission: model projections
Contraceptive use by couples when one partner is infected with HIV
Resisting the 'magic bullet' mentality: microbicides and existing barrier method approaches for women.
Is there a niche for a non-contraceptive vaginal microbicide?
Evaluation of safety and toxicity of rectal microbicides: Lessons learned from the first phase I trial of N-9 for rectal use
Assessing rectal microbicide acceptability: a case study, some lessons, and some questions
N-9 causes exfoliation of sheets of rectal epithelium
Accelerating the development of an AIDS vaccine for developing countries: an example of mechanisms available to the World Bank to increase investment in public goods
Harnessing the New Sciences for Health Equity
Mobilizing resources for microbicide development: an advocate's perspective
Microbicides-The Indian Scenario
The ethics of testing microbicides: are we protecting the volunteers or the investigators?
Secretory leukocyte protease inhibitor-an endogenous antimicrobial agent
The development of anti-microbial peptides of animal origin as vaginal microbicides: the challenges ahead and the potential
Mucosal antibodies as microbicides: potent, specific, and versatile
Nonnucleoside reverse transcriptase inhibitors as anti-HIV-1 microbicides
Antimicrobial peptides: from host defense to therapeutics
Rationale for testing chemokine inhibitors (Virustats) for prevention of HIV-1 transmission.
Microbicidal gel to prevent the transmission of pathogens causing sexually transmitted diseases
Mucosal delivery of microbicides by recombinant commensal bacteria: expression of the HIV-inactivating protein cyanovirin-N in gram-positive bacteria
Long-acting microbicide delivery system
The use of colposcopy in microbicide trials
Are there critical endpoints in phase I/II trials of vaginal microbicides?-A double-blind randomised controlled phase I study of 2% docusate sodium vaginal gel
Estimating leakage of vaginal products
A study on safety and tolerability of vaginal microbicides in females (SAHF)
Lessons learned from a microbicide acceptability study of women in Harare, Zimbabwe
Dilemmas in ethics, science and artefact: A South African perspective
Informed consent in microbicides testing
Microbicides research in the developing world: moral and ethical issues and the Indian context
Community consultation in northern Thailand: the Chiang Rai microbicide research community advisory group
Delay in possible prevention
Microbicide Research-Streamlining the Process
Microbicide Research-Streamlining the Process, Setting the Stage
Clinical Trials and Regulatory Issues in Developing Countries
Streamlining the Process & Regulatory Issues
Viral Load and Transmission in Uganda
Vaginal disinfection with benzalkonium chloride and vertical transmission of HIV-1 in West Africa: diatrame ANRS 049b trial
Microbicide market assessment from young women and men in California: baseline focus group findings
Track A: Basic Science
Track B: Clinical Science
Track C: Behavioral science and public health
Development of microbicides: WHO's perspective
The twin stories of Hanumanth Rao and Moses Ezekiel: the impact of reproductive health technologies on individual lives
Microbicides and HDV-infected Women
Closing remarks