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The persistence of GB virus C viremia in patients with chronic HIV-1 infection has been associated with increased survival. Elite suppressors are untreated HIV-1-infected patients who maintain viral loads of below 50 copies/ml. This study found that the frequency of GB virus C viremia in elite suppressors and chronically infected patients with progressive disease was not significantly different. Thus, GB virus C does not appear to explain the nonprogressive course seen in this cohort of elite suppressors.